Journal ArticleDOI
Role of mercury toxicity in hypertension, cardiovascular disease, and stroke
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This poster presents a probabilistic procedure to assess the importance of baseline IgE levels in the decision-making process and shows clear patterns in response to known immune-inflammatory events.Abstract:
Mercury has a high affinity for sulfhydryl groups, inactivating numerous enzymatic reactions, amino acids, and sulfur-containing antioxidants (N-acetyl-L-cysteine, alpha-lipoic acid, L-glutathione), with subsequent decreased oxidant defense and increased oxidative stress. Mercury binds to metallothionein and substitute for zinc, copper, and other trace metals, reducing the effectiveness of metalloenzymes. Mercury induces mitochondrial dysfunction with reduction in adenosine triphosphate, depletion of glutathione, and increased lipid peroxidation. Increased oxidative stress and reduced oxidative defense are common. Selenium and fish containing omega-3 fatty acids antagonize mercury toxicity. The overall vascular effects of mercury include increased oxidative stress and inflammation, reduced oxidative defense, thrombosis, vascular smooth muscle dysfunction, endothelial dysfunction, dyslipidemia, and immune and mitochondrial dysfunction. The clinical consequences of mercury toxicity include hypertension, coronary heart disease, myocardial infarction, cardiac arrhythmias, reduced heart rate variability, increased carotid intima-media thickness and carotid artery obstruction, cerebrovascular accident, generalized atherosclerosis, and renal dysfunction, insufficiency, and proteinuria. Pathological, biochemical, and functional medicine correlations are significant and logical. Mercury diminishes the protective effect of fish and omega-3 fatty acids. Mercury inactivates catecholaminei-0-methyl transferase, which increases serum and urinary epinephrine, norepinephrine, and dopamine. This effect will increase blood pressure and may be a clinical clue to mercury-induced heavy metal toxicity. Mercury toxicity should be evaluated in any patient with hypertension, coronary heart disease, cerebral vascular disease, cerebrovascular accident, or other vascular disease. Specific testing for acute and chronic toxicity and total body burden using hair, toenail, urine, and serum should be performed.read more
Citations
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What Did the Great Master Bach Die From
TL;DR: Feibel suggests that although they never met, these two great masters shared a physical contact through the operations by the same surgeon’s hands and contributed to the similarities between the two.
Journal ArticleDOI
An in-vivo microfluidic assay reveals cardiac toxicity of heavy metals and the protective effect of metal responsive transcription factor (MTF-1) in Drosophila model
Alireza Zabihihesari,Shahrzad Parand,A. Coulthard,Alexander Molnar,Arthur J. Hilliker,Pouya Rezai +5 more
TL;DR: A microfluidic-based cardiac toxicity assay illustrated that heart is an acute target of heavy metals toxicity, and MTF-1 overexpression in this tissue can ameliorate cardiac toxicity of Zn and Cd.
Research Article Ameliorating property of Morin-5'-Sulfonic acid sodium salt (NaMSA) on mercuric chloride (HgCl2) Induced histological changes in Albino rats
TL;DR: From the current investigation it is concluded that administration of mercury in sub-acute doses accumulates in the plasma, kidney, liver and heart, which in turn proportionately damages the liver, kidneys, testis andheart, whereas 50 mg/kg NaMSA administerd with HgCl2 protects the organs from mercury toxicity.
Posted ContentDOI
Fish Muscle Mercury Concentration and Bioaccumulation Fluctuate Year-Round - Insights from Cyprinid and Percid Fishes in a Humic Boreal Lake
La spiruline : indications thérapeutiques, risques sanitaires et conseils à l'officine
TL;DR: La spiruline, algue microscopique de composition riche et variee, est presentee comme ayant de nombreuses indications qu'il etait interessant de verifier, en pleine expansion a l'officine.
References
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Dietary supplementation with n-3 polyunsaturated fatty acids and vitamin E after myocardial infarction: results of the GISSI-Prevenzione trial
TL;DR: Dietary supplementation with n-3 PUFA led to a clinically important and statistically significant benefit and vitamin E had no benefit and its effects on fatal cardiovascular events require further exploration.
Journal ArticleDOI
Effects of changes in fat, fish, and fibre intakes on death and myocardial reinfarction: diet and reinfarction trial (dart)
Michael Leslie Burr,J. F. Gilbert,R. M. Holliday,Peter Creighton Elwood,Ann M. Fehily,S. Rogers,P. M. Sweetnam,N. M. Deadman +7 more
TL;DR: A modest intake of fatty fish (two or three portions per week) may reduce mortality in men who have recovered from MI.
Journal Article
The Environmental Protection Agency
TL;DR: A case study explores the background of the digitization project, the practices implemented, and the critiques of the project, which aims to provide access to a plethora of information to EPA employees, scientists, and researchers.