Journal ArticleDOI
Role of mercury toxicity in hypertension, cardiovascular disease, and stroke
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TLDR
This poster presents a probabilistic procedure to assess the importance of baseline IgE levels in the decision-making process and shows clear patterns in response to known immune-inflammatory events.Abstract:
Mercury has a high affinity for sulfhydryl groups, inactivating numerous enzymatic reactions, amino acids, and sulfur-containing antioxidants (N-acetyl-L-cysteine, alpha-lipoic acid, L-glutathione), with subsequent decreased oxidant defense and increased oxidative stress. Mercury binds to metallothionein and substitute for zinc, copper, and other trace metals, reducing the effectiveness of metalloenzymes. Mercury induces mitochondrial dysfunction with reduction in adenosine triphosphate, depletion of glutathione, and increased lipid peroxidation. Increased oxidative stress and reduced oxidative defense are common. Selenium and fish containing omega-3 fatty acids antagonize mercury toxicity. The overall vascular effects of mercury include increased oxidative stress and inflammation, reduced oxidative defense, thrombosis, vascular smooth muscle dysfunction, endothelial dysfunction, dyslipidemia, and immune and mitochondrial dysfunction. The clinical consequences of mercury toxicity include hypertension, coronary heart disease, myocardial infarction, cardiac arrhythmias, reduced heart rate variability, increased carotid intima-media thickness and carotid artery obstruction, cerebrovascular accident, generalized atherosclerosis, and renal dysfunction, insufficiency, and proteinuria. Pathological, biochemical, and functional medicine correlations are significant and logical. Mercury diminishes the protective effect of fish and omega-3 fatty acids. Mercury inactivates catecholaminei-0-methyl transferase, which increases serum and urinary epinephrine, norepinephrine, and dopamine. This effect will increase blood pressure and may be a clinical clue to mercury-induced heavy metal toxicity. Mercury toxicity should be evaluated in any patient with hypertension, coronary heart disease, cerebral vascular disease, cerebrovascular accident, or other vascular disease. Specific testing for acute and chronic toxicity and total body burden using hair, toenail, urine, and serum should be performed.read more
Citations
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Highly Sensitive and Selective Detection of Mercury (II) Ions with Fluorescent Au Nanodots
Yi Du,Zhiqin Yuan,Na Cai,Yan He +3 more
Journal ArticleDOI
Individual, Independent, and Joint Associations of Toxic Metals and Manganese on Hypertensive Disorders of Pregnancy: Results from the MIREC Canadian Pregnancy Cohort
TL;DR: In this article , individual, independent, and joint associations of lead, cadmium, As, Hg, and Mn on the risk of developing gestational hypertension and preeclampsia in a cohort of Canadian women were estimated.
Journal ArticleDOI
Heavy metals as risk factors for human diseases - a Bayesian network approach.
Marcello Perrelli,Roberto Lucchini,Laura del Bosque-Plata,Michael J. Vergare,Mohammed P. Akhter,J Ott,Claudia Gragnoli +6 more
TL;DR: The effects of low/moderate-level chronic heavy metal exposures are less known as they may be subclinical, and pathogenic effects may only manifest clinically over time under the disguise of a diagnosable disease or miscellaneous symptoms attributed to aging as mentioned in this paper .
Journal ArticleDOI
Association between prenatal metals exposure and blood pressure in 5-6 years children: A birth cohort study.
Yufan Ma,Chunmei Liang,Zihan Wang,Xin Wang,Liangliang Xie,Shuman Tao,Shuangqin Yan,Xiaoyan Wu,Zhaolian Wei,Juan Tong,Xingyong Tao,Fangbiao Tao +11 more
TL;DR: In this paper , a linear regression model and Bayesian kernel machine regression (BKMR) were used to explore associations between prenatal exposure to metals at different stages and multiple metal exposure with BP in children aged 5-6 years.
Journal ArticleDOI
Fluorescence Based Comparative Sensing Behavior of the Nano-Composites of SiO2 and TiO2 towards Toxic Hg2+ Ions.
Ekta,Divya Utreja +1 more
TL;DR: In this article, a sulfonamide based nano-composites of SiO2 and TiO2 was synthesized for selective and sensitive determination of toxic metal ion Hg2+ in aqueous medium.
References
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Dietary supplementation with n-3 polyunsaturated fatty acids and vitamin E after myocardial infarction: results of the GISSI-Prevenzione trial
TL;DR: Dietary supplementation with n-3 PUFA led to a clinically important and statistically significant benefit and vitamin E had no benefit and its effects on fatal cardiovascular events require further exploration.
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The Environmental Protection Agency
TL;DR: A case study explores the background of the digitization project, the practices implemented, and the critiques of the project, which aims to provide access to a plethora of information to EPA employees, scientists, and researchers.