Journal ArticleDOI
Role of mercury toxicity in hypertension, cardiovascular disease, and stroke
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This poster presents a probabilistic procedure to assess the importance of baseline IgE levels in the decision-making process and shows clear patterns in response to known immune-inflammatory events.Abstract:
Mercury has a high affinity for sulfhydryl groups, inactivating numerous enzymatic reactions, amino acids, and sulfur-containing antioxidants (N-acetyl-L-cysteine, alpha-lipoic acid, L-glutathione), with subsequent decreased oxidant defense and increased oxidative stress. Mercury binds to metallothionein and substitute for zinc, copper, and other trace metals, reducing the effectiveness of metalloenzymes. Mercury induces mitochondrial dysfunction with reduction in adenosine triphosphate, depletion of glutathione, and increased lipid peroxidation. Increased oxidative stress and reduced oxidative defense are common. Selenium and fish containing omega-3 fatty acids antagonize mercury toxicity. The overall vascular effects of mercury include increased oxidative stress and inflammation, reduced oxidative defense, thrombosis, vascular smooth muscle dysfunction, endothelial dysfunction, dyslipidemia, and immune and mitochondrial dysfunction. The clinical consequences of mercury toxicity include hypertension, coronary heart disease, myocardial infarction, cardiac arrhythmias, reduced heart rate variability, increased carotid intima-media thickness and carotid artery obstruction, cerebrovascular accident, generalized atherosclerosis, and renal dysfunction, insufficiency, and proteinuria. Pathological, biochemical, and functional medicine correlations are significant and logical. Mercury diminishes the protective effect of fish and omega-3 fatty acids. Mercury inactivates catecholaminei-0-methyl transferase, which increases serum and urinary epinephrine, norepinephrine, and dopamine. This effect will increase blood pressure and may be a clinical clue to mercury-induced heavy metal toxicity. Mercury toxicity should be evaluated in any patient with hypertension, coronary heart disease, cerebral vascular disease, cerebrovascular accident, or other vascular disease. Specific testing for acute and chronic toxicity and total body burden using hair, toenail, urine, and serum should be performed.read more
Citations
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Effects of fatty and lean fish intake on stroke risk: a meta-analysis of prospective cohort studies.
TL;DR: It is demonstrated that fatty and lean fish intake has beneficial effects on stroke risk, especiallyLean fish intake, especially fatty fish intake.
Journal ArticleDOI
Co-exposure of silica nanoparticles and methylmercury induced cardiac toxicity in vitro and in vivo.
Xiaozhe Yang,Lin Feng,Yannan Zhang,Hejing Hu,Yanfeng Shi,Shuang Liang,Tong Zhao,Lige Cao,Junchao Duan,Zhiwei Sun +9 more
TL;DR: Investigation of the co-exposure cardiac toxicity of silica nanoparticles and methylmercury showed severe cardiac toxicity induced by co-Exposure of SiNPs and MeHg in both cardiomycytes and heart.
Journal ArticleDOI
The effect of different sources of fish and camelina sativa oil on immune cell and adipose tissue mRNA expression in subjects with abnormal fasting glucose metabolism: a randomized controlled trial.
Vanessa D. de Mello,Ingrid Dahlman,Maria Lankinen,Sudhir Kurl,Leena Pitkänen,David E. Laaksonen,Ursula Schwab,Arja T. Erkkilä +7 more
TL;DR: In this paper, the authors examined whether diets enriched in fatty fish (FF), lean fish (LF) or ALA-rich camelina sativa oil (CSO) differ in their effects on the mRNA expression response of selected inflammation-related genes in peripheral blood mononuclear cells (PBMCs) and subcutaneous adipose tissue (SAT) in subjects with impaired fasting glucose.
Journal ArticleDOI
Associations between total mercury and methyl mercury exposure and cardiovascular risk factors in US adolescents
TL;DR: It is suggested that blood MeHg may be positively associated with total cholesterol in adolescent girls, and more research is needed to verify this association and to elucidate its underlying mechanisms.
Journal ArticleDOI
Toxic effects of chronic mercury exposure on the retinal nerve fiber layer and macular and choroidal thickness in industrial mercury battery workers.
Metin Ekinci,Erdinç Ceylan,Sadullah Keles,Halil Hüseyin Çağatay,Aytekin Apil,Burak Tanyıldız,Gunay Uludag +6 more
TL;DR: SD-OCT can be useful for evaluating the toxic effects of chronic exposure to mercury by using spectral-domain optical coherence tomography in battery industry workers who had been chronically exposed to mercury.
References
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Dietary supplementation with n-3 polyunsaturated fatty acids and vitamin E after myocardial infarction: results of the GISSI-Prevenzione trial
TL;DR: Dietary supplementation with n-3 PUFA led to a clinically important and statistically significant benefit and vitamin E had no benefit and its effects on fatal cardiovascular events require further exploration.
Journal ArticleDOI
Effects of changes in fat, fish, and fibre intakes on death and myocardial reinfarction: diet and reinfarction trial (dart)
Michael Leslie Burr,J. F. Gilbert,R. M. Holliday,Peter Creighton Elwood,Ann M. Fehily,S. Rogers,P. M. Sweetnam,N. M. Deadman +7 more
TL;DR: A modest intake of fatty fish (two or three portions per week) may reduce mortality in men who have recovered from MI.
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The Environmental Protection Agency
TL;DR: A case study explores the background of the digitization project, the practices implemented, and the critiques of the project, which aims to provide access to a plethora of information to EPA employees, scientists, and researchers.