Journal ArticleDOI
Role of mercury toxicity in hypertension, cardiovascular disease, and stroke
TLDR
This poster presents a probabilistic procedure to assess the importance of baseline IgE levels in the decision-making process and shows clear patterns in response to known immune-inflammatory events.Abstract:
Mercury has a high affinity for sulfhydryl groups, inactivating numerous enzymatic reactions, amino acids, and sulfur-containing antioxidants (N-acetyl-L-cysteine, alpha-lipoic acid, L-glutathione), with subsequent decreased oxidant defense and increased oxidative stress. Mercury binds to metallothionein and substitute for zinc, copper, and other trace metals, reducing the effectiveness of metalloenzymes. Mercury induces mitochondrial dysfunction with reduction in adenosine triphosphate, depletion of glutathione, and increased lipid peroxidation. Increased oxidative stress and reduced oxidative defense are common. Selenium and fish containing omega-3 fatty acids antagonize mercury toxicity. The overall vascular effects of mercury include increased oxidative stress and inflammation, reduced oxidative defense, thrombosis, vascular smooth muscle dysfunction, endothelial dysfunction, dyslipidemia, and immune and mitochondrial dysfunction. The clinical consequences of mercury toxicity include hypertension, coronary heart disease, myocardial infarction, cardiac arrhythmias, reduced heart rate variability, increased carotid intima-media thickness and carotid artery obstruction, cerebrovascular accident, generalized atherosclerosis, and renal dysfunction, insufficiency, and proteinuria. Pathological, biochemical, and functional medicine correlations are significant and logical. Mercury diminishes the protective effect of fish and omega-3 fatty acids. Mercury inactivates catecholaminei-0-methyl transferase, which increases serum and urinary epinephrine, norepinephrine, and dopamine. This effect will increase blood pressure and may be a clinical clue to mercury-induced heavy metal toxicity. Mercury toxicity should be evaluated in any patient with hypertension, coronary heart disease, cerebral vascular disease, cerebrovascular accident, or other vascular disease. Specific testing for acute and chronic toxicity and total body burden using hair, toenail, urine, and serum should be performed.read more
Citations
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Journal ArticleDOI
Mercury exposure and omega-3 fatty acid intake in relation to renal function in the US population.
TL;DR: It is demonstrated that Hg exposure is associated with increased odds of having lower GFR in the US population aged 40 or above, and that omega-3 FA intake may play a preventive role in Hg-induced nephrotoxicity.
Journal ArticleDOI
Cerebrovascular endothelial dysfunction induced by mercury exposure at low concentrations.
Giulia Alessandra Wiggers,Giulia Alessandra Wiggers,Lorena Barros Furieri,Lorena Barros Furieri,Ana M. Briones,María S. Avendaño,Franck Maciel Peçanha,Franck Maciel Peçanha,Dalton Valentim Vassallo,Mercedes Salaices,María J. Alonso +10 more
TL;DR: Findings show, for the first time, that brain vasculature are also affected by chronic mercury exposure and offer further evidence that even at small concentration, HgCl2 is hazardous and might be an environmental risk factor accounting for cerebral vasospasm development.
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Mercury Toxicity: Ecological Features of Organic Phase of Mercury in Biota- Part I
Loai Aljerf,Nuha AlMasri +1 more
TL;DR: In this paper, the half-life of methylmercury in human is about 70 days and the conversion of mercury element to its organic species has been illustrated in biological and marine environments.
Journal ArticleDOI
The Herbicide Glyphosate and Its Apparently Controversial Effect on Human Health: An Updated Clinical Perspective
TL;DR: The controversy about the dangers of the product for human beings is untangled in view of a very recent development, when the so -called Monsanto Papers came to light, revealing a coordinated strategy to manipulate the debate about the safety of glyphosate to the company's advantage.
Journal ArticleDOI
The association between low blood lead levels and the prevalence of prehypertension among nonhypertensive adults in Korea.
Wanhyung Lee,Jin Ha Yoon,Jaehoon Roh,Seung-Hyun Lee,Hongdeok Seok,June-Hee Lee,Pil Kyun Jung,Jeongbae Rhie,Jong Uk Won +8 more
TL;DR: The association between blood lead levels below the threshold for the harmful effects of lead and the prevalence of prehypertension in Korean adults is investigated.
References
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Journal ArticleDOI
Dietary supplementation with n-3 polyunsaturated fatty acids and vitamin E after myocardial infarction: results of the GISSI-Prevenzione trial
TL;DR: Dietary supplementation with n-3 PUFA led to a clinically important and statistically significant benefit and vitamin E had no benefit and its effects on fatal cardiovascular events require further exploration.
Journal ArticleDOI
Effects of changes in fat, fish, and fibre intakes on death and myocardial reinfarction: diet and reinfarction trial (dart)
Michael Leslie Burr,J. F. Gilbert,R. M. Holliday,Peter Creighton Elwood,Ann M. Fehily,S. Rogers,P. M. Sweetnam,N. M. Deadman +7 more
TL;DR: A modest intake of fatty fish (two or three portions per week) may reduce mortality in men who have recovered from MI.
Journal Article
The Environmental Protection Agency
TL;DR: A case study explores the background of the digitization project, the practices implemented, and the critiques of the project, which aims to provide access to a plethora of information to EPA employees, scientists, and researchers.