Journal ArticleDOI
Role of protein kinase C in the inhibition by fibroblast growth factor of apoptosis in serum-depleted endothelial cells.
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The results suggest that the FGF and protein kinase C are important in endothelial apoptosis.About:
This article is published in Biochemical and Biophysical Research Communications.The article was published on 1990-11-15. It has received 123 citations till now. The article focuses on the topics: Vascular endothelial growth factor A & Vascular endothelial growth factor B.read more
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Vascular Endothelial Growth Factor Regulates Endothelial Cell Survival through the Phosphatidylinositol 3′-Kinase/Akt Signal Transduction Pathway REQUIREMENT FOR Flk-1/KDR ACTIVATION
Hans-Peter Gerber,Amy McMurtrey,Joe Kowalski,Minhong Yan,Bruce Keyt,Vishva M. Dixit,Napoleone Ferrara +6 more
TL;DR: The Flk-1/KDR receptor and the PI3-kinase/Akt signal transduction pathway are identified as crucial elements in the processes leading to endothelial cell survival induced by VEGF, and inhibition of apoptosis may represent a major aspect of the regulatory activity of V EGF on the vascular endothelium.
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The Emerging Concept of Vascular Remodeling
Gary H. Gibbons,Victor J. Dzau +1 more
TL;DR: Vascular remodeling is an active process of structural alteration that involves changes in at least four cellular processes -- cell growth, cell death, cell migration, and production or degradation of extracellular matrix -- and is dependent on a dynamic interaction between locally.
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Apoptosis: the biochemistry and molecular biology of programmed cell death.
TL;DR: This review first briefly covers some historical perspective on the discovery of apoptotic cell death, the characteristic morphology that accompanies this process, and the numerous cell types and mediators with which programmed cell death is associated.
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Angiopoietin-1 Regulates Endothelial Cell Survival Through the Phosphatidylinositol 3′-Kinase/Akt Signal Transduction Pathway
TL;DR: Findings indicate that the Tie2 receptor, PI 3'-kinase, and Akt are crucial elements in the signal transduction pathway leading to endothelial cell survival induced by the paracrine activity of Ang1.
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The role of DNA fragmentation in apoptosis.
TL;DR: The formation of distinct DNA fragments of oligonucleosomal size (180-200 bp lengths) is a biochemical hallmark of apoptosis in many cells and recent observations suggest large DNA fragments and even single-strand cleavage events occur during cell death.
References
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Apoptosis: a basic biological phenomenon with wide-ranging implications in tissue kinetics.
TL;DR: Apoptosis seems to be involved in cell turnover in many healthy adult tissues and is responsible for focal elimination of cells during normal embryonic development, and participates in at least some types of therapeutically induced tumour regression.
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Culture of Human Endothelial Cells Derived from Umbilical Veins. IDENTIFICATION BY MORPHOLOGIC AND IMMUNOLOGIC CRITERIA
TL;DR: It is demonstrated that it is possible to culture morphologically and immunologically identifiable human endothelial cells for periods up to 5 mo and ABH antigens appropriate to the tissue donor's blood type were not detectable on cultured smooth muscle cells or fibroblasts.
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Glucocorticoid-induced thymocyte apoptosis is associated with endogenous endonuclease activation
TL;DR: It is shown here that this morphological change is closely associated with excision of nucleosome chains from nuclear chromatin, apparently through activation of an intracellular, but non-lysosomal, endonuclease.
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Angiogenesis in vitro
TL;DR: This first demonstration of angiogenesis in vitro shows that all the information necessary to develop an entire capillary network in vitro is expressed by one cell type, suggests a mechanism for lumen formation, and offers a possibility of distinguishing between direct and indirectAngiogenesis factors.
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Multiple, distinct forms of bovine and human protein kinase C suggest diversity in cellular signaling pathways.
Lisa M. Coussens,Peter J. Parker,Lucy Rhee,Teresa L. Yang-Feng,Ellson Y. Chen,Michael D. Waterfield,Uta Francke,Axel Ullrich +7 more
TL;DR: A new family of protein kinase C-related genes has been identified in bovine, human, and rat genomes that are highly homologous, include a kinase domain, and potential calcium-binding sites, and they contain interspersed variable regions.