Journal ArticleDOI
Safety and efficacy of sperm washing in HIV-1-serodiscordant couples where the male is infected: results from the European CREAThE network.
Louis Bujan,Lital Hollander,Mathieu Coudert,Carole Gilling-Smith,Alexandra Vucetich,Juliette Guibert,Pietro Vernazza,Jeanine Ohl,Michael Weigel,Yvon Englert,Augusto E. Semprini +10 more
Reads0
Chats0
TLDR
The view that assisted reproduction with sperm washing could not be denied to serodiscordant couples in developed countries and, where possible, could perhaps be integrated into a global public health initiative against HIV in developing countries is supported.Abstract:
Objective: To examine the safety and effectiveness of assisted reproduction using sperm washing for HIV-1-serodiscordant couples wishing to procreate where the male partner is infected. Design and methods: A retrospective multicentre study at eight centres adhering on the European network CREAThE and involving 1036 serodiscordant couples wishing to procreate. Sperm washing was used to obtain motile spermatozoa for 3390 assisted reproduction cycles (2840 intrauterine inseminations, 107 in-vitro fertilizations, 394 intra-cytoplasmic sperm injections and 49 frozen embryo transfers). An HIV test was performed in female partners at least 6 months after assisted reproduction attempt. The outcome measures recorded were number of assisted reproduction cycles, pregnancy outcome and HIV test on women post-treatment. Results: A total of 580 pregnancies were obtained from 3315 cycles. Pregnancy outcome was unknown in 47 cases. The 533 pregnancies resulted in 410 deliveries and 463 live births. The result of female HIV testing after assisted reproduction was known in 967 out of 1036 woman (7.1% lost to follow-up). All tests recorded were negative. The calculated probability of contamination was equal to zero (95% confidence interval, 0‐0.09%). Conclusion: This first multicentre retrospective study of assisted reproduction following sperm washing demonstrates the method to be effective and to significantly reduce HIV1 transmission risk to the uninfected female partner. These results support the view that assisted reproduction with sperm washing could not be denied to serodiscordant couples in developed countries and, where possible, could perhaps be integrated into a global public health initiative against HIV in developing countries.read more
Citations
More filters
Journal ArticleDOI
Preexposure prophylaxis and timed intercourse for HIV-discordant couples willing to conceive a child.
TL;DR: This study offered timed intercourse combined with preexposure prophylaxis to further reduce the transmission risk in HIV-discordant couples and found that advanced age in the female partner was a predictor for infertility in these couples.
Journal ArticleDOI
British HIV Association and Children's HIV Association guidelines for the management of HIV infection in pregnant women 2008
A de Ruiter,Danielle Mercey,Jane Anderson,Rana Chakraborty,P Clayden,Graham R. Foster,C. Gilling-Smith,D Hawkins,Naomi Low-Beer,Hermione Lyall,S O'Shea,Z Penn,J Short,Richard P. Smith,S Sonecha,Pat A Tookey,C Wood,Graham P. Taylor +17 more
TL;DR: In this paper, the authors presented a summary of recommendations for reducing mother-to-child transmission of HIV in pregnant women, including interventions to reduce mother to child transmission of the virus.
Journal ArticleDOI
Detection of HIV-1 RNA in seminal plasma samples from treated patients with undetectable HIV-1 RNA in blood plasma.
Anne-Geneviève Marcelin,Roland Tubiana,Sidonie Lambert-Niclot,Gilles Lefebvre,Stéphanie Dominguez,Manuela Bonmarchand,Daniele Vauthier-Brouzes,Françoise Marguet,Nathalie Mousset-Simeon,Gilles Peytavin,Catherine Poirot +10 more
TL;DR: This result justifies measuring HIV-1 RNA in semen before the ART process and suggests that a residual risk of transmission has to be mentioned to the patients who would like to have unprotected sexual intercourse.
Journal ArticleDOI
British HIV Association, BASHH and FSRH guidelines for the management of the sexual and reproductive health of people living with HIV infection 2008
A Fakoya,H Lamba,Nicola Mackie,R Nandwani,Abbe Brown,Edwin J Bernard,C Gilling-Smith,Charles J.N. Lacey,Lorraine Sherr,P Claydon,S Wallage,Brian Gazzard +11 more
TL;DR: A Fakoya, H Lamba, N Mackie, R Nandwani, A Brown, EJ Bernard, C Gilling-Smith, C Lacey, L Sherr, P Claydon, S Wallage and B Gazzard
Journal ArticleDOI
Achieving safe conception in HIV-discordant couples: the potential role of oral preexposure prophylaxis (PrEP) in the United States.
TL;DR: The question is whether it contributes to lowering risk in couples who have decided to conceive despite known risks, and the unknown risks of preexposure prophylaxis used during conception and early fetal development should be considered.
References
More filters
Journal ArticleDOI
If Nothing Goes Wrong, Is Everything All Right?: Interpreting Zero Numerators
TL;DR: The occurrence of "no events" seems to be viewed as very different both quantitatively and qualitatively from the occurrence of one or more events, so it is useful to look into some of the statistical and psychological issues that influence the occurrence.
Journal ArticleDOI
A Longitudinal Study of Human Immunodeficiency Virus Transmission by Heterosexual Partners
TL;DR: A prospective study of HIV-negative subjects whose only risk of HIV infection was a stable heterosexual relationship with an HIV-infected partner, finding that only 124 couples who continued to have sexual relations for more than three months after enrollment in the study, used condoms consistently for vaginal and anal intercourse.
Journal ArticleDOI
Human immunodeficiency virus type 1 in the semen of men receiving highly active antiretroviral therapy
TL;DR: In HIV-1-infected men who are receiving highly active antiretroviral therapy and who have no detectable levels of viral RNA in plasma the virus may be present in seminal cells and therefore may be capable of being transmitted sexually.
Journal ArticleDOI
Effectiveness of highly active antiretroviral therapy in reducing heterosexual transmission of HIV.
Jesús Castilla,Jorge del Romero,Victoria Hernando,Beatriz Marincovich,S García,Carmen Rodríguez +5 more
TL;DR: When HAART became widely available, a reduction of approximately 80% in heterosexual transmission of HIV was observed, irrespective of changes in other factors that affect transmission.
Journal ArticleDOI
Fertility desires and intentions of HIV-positive men and women.
TL;DR: The fact that many HIV-infected adults desire and expect to have children has important implications for the prevention of vertical and heterosexual transmission of HIV, the need for counseling to facilitate informed decision-making about childbearing and childrearing, and the future demand for social services for children born to infected parents.
Related Papers (5)
Prevention of HIV-1 Infection with Early Antiretroviral Therapy
Myron S. Cohen,Ying Q. Chen,Marybeth McCauley,Theresa Gamble,Mina C. Hosseinipour,Nagalingeswaran Kumarasamy,James Hakim,Johnstone Kumwenda,Beatriz Grinsztejn,José Henrique Pilotto,Sheela Godbole,Sanjay Mehendale,Suwat Chariyalertsak,Breno Santos,Kenneth H. Mayer,Irving F. Hoffman,Susan H. Eshleman,Estelle Piwowar-Manning,Lei Wang,Joseph Makhema,Lisa A. Mills,Guy de Bruyn,Ian Sanne,Joseph J. Eron,Joel E. Gallant,Diane V. Havlir,Susan Swindells,Heather J. Ribaudo,Vanessa Elharrar,David N. Burns,Taha E. Taha,Karin Nielsen-Saines,David D. Celentano,Myron Essex,Thomas R. Fleming +34 more