Journal ArticleDOI
Salicylate evokes c-fos expression in the brain stem: implications for tinnitus
TLDR
Results suggest that salicylate may evoke tinnitus through a combined effect on auditory and non-auditory brain nuclei, while activity in auditory brain stem nuclei is reduced, stress-susceptible areas are activated.Abstract:
SUBJECTIVE tinnitus, a distracting internal noise is experienced by humans and animals. Mongolian gerbils were treated with salicylate as a tinnitus-evoking agent. After salicylate treatment, c-fos expression in auditory brain stem nuclei was as low as after saline treatment (control). Pronounced differences between groups were found, however, in areas susceptible to stress, with many immunoreactive cells in the locus coeruleus, the midbrain periaqueductal grey and the lateral parabrachial nucleus of salicylate-treated animals. These results suggest that salicylate may evoke tinnitus through a combined effect on auditory and non-auditory brain nuclei. While activity in auditory brain stem nuclei is reduced, stress-susceptible areas are activated. It seems possible that the interaction of these effects at particular locations of the brain causes tinnitus.read more
Citations
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Journal ArticleDOI
The Pharmacological Basis of Therapeutics
TL;DR: The Pharmacological Basis of Therapeutics, by Prof. Louis Goodman and Prof. Alfred Gilman, New York: The Macmillan Company, 1941, p.
Journal ArticleDOI
Plastic changes in the central auditory system after hearing loss, restoration of function, and during learning.
TL;DR: A better understanding of the plastic changes in the central auditory system after sensory deafferentation, sensory stimulation, and learning may contribute significantly to improvement in the rehabilitation of damaged or lost auditory function and consequently to improved speech processing and production.
Journal ArticleDOI
Lateralized tinnitus studied with functional magnetic resonance imaging: abnormal inferior colliculus activation.
Jennifer R. Melcher,Irina S. Sigalovsky,Irina S. Sigalovsky,John J. Guinan,John J. Guinan,John J. Guinan,Robert A. Levine +6 more
TL;DR: FMRI can provide objective measures of lateralized tinnitus and tinn Titus-related activation can be interpreted at a neural level, and this work demonstrates that fMRI is effective in revealingTinnitus-related abnormalities in brain function.
Book ChapterDOI
Pathophysiology of tinnitus
TL;DR: Several morphological and physiological substrates of tinnitus in animal studies are reviewed, including changes in ion channels, receptor systems, single unit firing rate, and population responses.
Journal ArticleDOI
Mechanisms of tinnitus.
TL;DR: Possible mechanisms for tinnitus within the auditory brain are reviewed, including important work on synchronised spontaneous activity in the cochlear nerve, and the concept of discordant damage between inner and outer hair cells is described.
References
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Journal ArticleDOI
The Pharmacological Basis of Therapeutics
TL;DR: The Pharmacological Basis of Therapeutics, by Prof. Louis Goodman and Prof. Alfred Gilman, New York: The Macmillan Company, 1941, p.
Journal ArticleDOI
Nucleus locus ceruleus: new evidence of anatomical and physiological specificity
Journal ArticleDOI
Expression of C-fos-like protein as a marker for neuronal activity following noxious stimulation in the rat
TL;DR: The data suggest that c‐fos can be used as a transynaptic marker for neuronal activity following noxious stimulation, however, c‐ fos is expressed only in some kinds of neurons following peripheral stimulation, and it therefore may be an incomplete marker for nociresponsive activity.
Journal ArticleDOI
The locus coeruleus: a cytoarchitectonic, Golgi and immunohistochemical study in the albino rat.
TL;DR: Two general classes of medium-sized neuron were found in the locus coeruleus in Nissl- and DBH-stained material: multipolar and somewhat smaller fusiform cells; both types of neuron have relatively long thin dendrites which extend well beyond the limits of the nucleus into surrounding neuropil and nuclear areas.
Journal ArticleDOI
Spatially and temporally differentiated patterns of c-fos expression in brainstem catecholaminergic cell groups induced by cardiovascular challenges in the rat.
TL;DR: Findings underscore the importance of brainstem catecholaminergic neurons in effecting integrated homeostatic responses to cardiovascular challenges and their ability to responding strategically to specific modalities of cardiovascular information.