Scalable privacy-preserving data sharing methodology for genome-wide association studies.
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This work extends the methods developed in Uhler et al. (2013) for releasing differentially-private χ(2)-statistics by allowing for arbitrary number of cases and controls, and provides a new interpretation by assuming the controls' data are known, which is a realistic assumption because some GWAS use publicly available data as controls.About:
This article is published in Journal of Biomedical Informatics.The article was published on 2014-08-01 and is currently open access. It has received 159 citations till now. The article focuses on the topics: Differential privacy.read more
Citations
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Journal ArticleDOI
Routes for breaching and protecting genetic privacy.
Yaniv Erlich,Arvind Narayanan +1 more
TL;DR: An overview of genetic privacy breaching strategies is presented, outlining the principles of each technique, the underlying assumptions, and their technological complexity and maturation, as well as highlighting different cases that are relevant to genetic applications.
Journal ArticleDOI
Technical Privacy Metrics: A Systematic Survey
Isabel Wagner,David Eckhoff +1 more
TL;DR: A survey of privacy metrics can be found in this article, where the authors discuss a selection of over 80 privacy metrics and introduce categorizations based on the aspect of privacy they measure, their required inputs, and the type of data that needs protection.
Journal ArticleDOI
Privacy in the Genomic Era
Muhammad Naveed,Erman Ayday,Ellen Wright Clayton,Jacques Fellay,Carl A. Gunter,Jean-Pierre Hubaux,Bradley A. Malin,XiaoFeng Wang +7 more
TL;DR: An enumeration of the challenges for genome data privacy is enumerated and a framework to systematize the analysis of threats and the design of countermeasures as the field moves forward is presented.
Journal ArticleDOI
Exposed! A Survey of Attacks on Private Data
TL;DR: This survey focuses on attacking aggregate data, such as statistics about how many individuals have a certain disease, genetic trait, or combination thereof, and considers two types of attacks: reconstruction attacks, which approximately determine a sensitive feature of all the individuals covered by the dataset, and tracing attacks,Which determine whether or not a target individual's data are included in the dataset.
Posted Content
Privacy in the Genomic Era
Muhammad Naveed,Erman Ayday,Ellen Wright Clayton,Jacques Fellay,Carl A. Gunter,Jean-Pierre Hubaux,Bradley A. Malin,XiaoFeng Wang +7 more
TL;DR: The problem of genome data privacy is at the crossroads of computer science, medicine, and public policy as discussed by the authors, and the state-of-the-art regarding privacy attacks on genomic data and strategies for mitigating such attacks, as well as contextualizing these attacks from the perspective of medicine and public policies.
References
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Journal ArticleDOI
Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls
Paul Burton,David Clayton,Lon R. Cardon,Nicholas John Craddock,Panos Deloukas,Audrey Duncanson,Dominic P. Kwiatkowski,Mark I. McCarthy,Willem H. Ouwehand,Nilesh J. Samani,John A. Todd,Peter Donnelly,Jeffrey C. Barrett,Dan Davison,Doug Easton,David M. Evans,H. T. Leung,Jonathan Marchini,Andrew P. Morris,Chris C. A. Spencer,Martin D. Tobin,Antony P. Attwood,James P. Boorman,Barbara Cant,Ursula Everson,Judith M. Hussey,Jennifer Jolley,Alexandra S. Knight,Kerstin Koch,Elizabeth Meech,Sarah Nutland,Christopher Prowse,Helen Stevens,Niall C. Taylor,Graham R. Walters,Neil Walker,Nicholas A. Watkins,Thilo Winzer,Richard Jones,Wendy L. McArdle,Susan M. Ring,David P. Strachan,Marcus Pembrey,Gerome Breen,David St Clair,Sian Caesar,Katherine Gordon-Smith,Lisa Jones,Christine Fraser,Elaine K. Green,Detelina Grozeva,Marian L. Hamshere,Peter Holmans,Ian Jones,George Kirov,Valentina Moskvina,Ivan Nikolov,Michael Conlon O'Donovan,Michael John Owen,David A. Collier,Amanda Elkin,Anne Farmer,Richard Williamson,Peter McGuffin,Allan H. Young,I. Nicol Ferrier,Stephen G. Ball,Anthony J. Balmforth,Jennifer H. Barrett,D. Timothy Bishop,Mark M. Iles,Azhar Maqbool,Nadira Yuldasheva,Alistair S. Hall,Peter S. Braund,Richard J. Dixon,Massimo Mangino,Suzanne Stevens,John R. Thompson,Francesca Bredin,Mark Tremelling,Miles Parkes,Hazel E. Drummond,Charlie W. Lees,Elaine R. Nimmo,Jack Satsangi,Sheila A. Fisher,Alastair Forbes,Cathryn M. Lewis,Clive M. Onnie,Natalie J. Prescott,Jeremy D. Sanderson,Christopher G. Mathew,Jamie Barbour,M. Khalid Mohiuddin,Catherine E. Todhunter,John C. Mansfield,Tariq Ahmad,Fraser Cummings,Derek P. Jewell,John Webster,Morris J. Brown,G. Mark Lathrop,John M. C. Connell,Anna F. Dominiczak,Carolina A. Braga Marcano,Beverley Burke,Richard Dobson,Johannie Gungadoo,Kate L. Lee,Patricia B. Munroe,Stephen Newhouse,Abiodun Onipinla,Chris Wallace,Mingzhan Xue,Mark J. Caulfield,Martin Farrall,Anne Barton,Ian N. Bruce,Hannah Donovan,Steve Eyre,Paul D. Gilbert,Samantha L. Hider,Anne Hinks,Sally John,Catherine Potter,Alan J. Silman,Deborah P M Symmons,Wendy Thomson,Jane Worthington,David B. Dunger,Barry Widmer,Timothy M. Frayling,Rachel M. Freathy,Hana Lango,John R. B. Perry,Beverley M. Shields,Michael N. Weedon,Andrew T. Hattersley,Graham A. Hitman,Mark Walker,Kate S. Elliott,Christopher J. Groves,Cecilia M. Lindgren,Nigel W. Rayner,Nicholas J. Timpson,Eleftheria Zeggini,Melanie J. Newport,Giorgio Sirugo,Emily J. Lyons,Fredrik O. Vannberg,Adrian V. S. Hill,Linda A. Bradbury,C Farrar,J J Pointon,Paul Wordsworth,Matthew A. Brown,Jayne A. Franklyn,Joanne M. Heward,Matthew J. Simmonds,Stephen C. L. Gough,Sheila Seal,Michael R. Stratton,Nazneen Rahman,Maria Ban,An Goris,Stephen Sawcer,Alastair Compston,David J. Conway,Muminatou Jallow,Kirk A. Rockett,Suzannah Bumpstead,Amy Chaney,Kate Downes,Mohammed J. R. Ghori,Rhian Gwilliam,Sarah E. Hunt,Michael Inouye,Andrew Keniry,Emma King,Ralph McGinnis,Simon C. Potter,Rathi Ravindrarajah,Pamela Whittaker,Claire Widden,David Withers,Niall Cardin,Teresa Ferreira,Joanne Pereira-Gale,Ingileif B. Hallgrímsdóttir,Bryan Howie,Zhan Su,Yik Ying Teo,Damjan Vukcevic,David Bentley,A Compston +195 more
TL;DR: This study has demonstrated that careful use of a shared control group represents a safe and effective approach to GWA analyses of multiple disease phenotypes; generated a genome-wide genotype database for future studies of common diseases in the British population; and shown that, provided individuals with non-European ancestry are excluded, the extent of population stratification in theBritish population is generally modest.
Book ChapterDOI
Calibrating noise to sensitivity in private data analysis
TL;DR: In this article, the authors show that for several particular applications substantially less noise is needed than was previously understood to be the case, and also show the separation results showing the increased value of interactive sanitization mechanisms over non-interactive.
Journal Article
Calibrating noise to sensitivity in private data analysis
TL;DR: The study is extended to general functions f, proving that privacy can be preserved by calibrating the standard deviation of the noise according to the sensitivity of the function f, which is the amount that any single argument to f can change its output.
Journal ArticleDOI
Genomic control for association studies.
Bernie Devlin,Kathryn Roeder +1 more
TL;DR: The performance of the genomic control method is quite good for plausible effects of liability genes, which bodes well for future genetic analyses of complex disorders.
Proceedings ArticleDOI
Mechanism Design via Differential Privacy
Frank McSherry,Kunal Talwar +1 more
TL;DR: It is shown that the recent notion of differential privacv, in addition to its own intrinsic virtue, can ensure that participants have limited effect on the outcome of the mechanism, and as a consequence have limited incentive to lie.