Journal ArticleDOI
Secondary hypersomnia as an initial manifestation of neuromyelitis optica spectrum disorders
Ysoline Beigneux,Isabelle Arnulf,Perrine Guillaume-Jugnot,Smaranda Leu-Semenescu,Elisabeth Maillart,Catherine Lubetzki,Olivier Benveniste,C. Papeix +7 more
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TLDR
Diencephalic form of NMO/SD seems to cause narcolepsy or non-narcoleptic central hypersomnia and have a good recovery without psychostimulant treatment.Abstract:
The identification of AQP4-IgG, a specific and pathogenic antibody of NMO/SD has led to a broadening of the clinical spectrum of manifestations of NMO/SD including the presence of encephalic symptoms. Lesions are often distributed on peri‑ependymal area and sometimes affected the diencephalon leading to sleep disorders. We report a case of hypersomnia with polysomnographic documentation during the first attack of NMO/SD. Brain MRI revealed bilateral hypothalamic lesions around the third ventricle, whereas optic nerves and spinal cord were intact. The record of the nocturnal video-polysomnography followed by multiple sleep latency tests (MSLT) revealed an abnormal shortened sleep period with a single sleep onset in REM allowing secondary central hypersomnia diagnosis. The recovery of hypersomnia was complete within few months without psychostimulant treatment and the diencephalic lesion disappeared. Thus, diencephalic form of NMO/SD seems to cause narcolepsy or non-narcoleptic central hypersomnia and have a good recovery.read more
Citations
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Journal ArticleDOI
Current and emerging biologics for the treatment of neuromyelitis optica spectrum disorders.
Ankelien Duchow,Ankelien Duchow,Friedemann Paul,Friedemann Paul,Judith Bellmann-Strobl,Judith Bellmann-Strobl +5 more
TL;DR: The first drug for the therapy of anti-aquaporin-4 (AQP4) antibody-seropositive NMOSD patients has been approved in 2019: the C5 complement inhibitor eculizumab, followed by an overview of emerging drugs in less advanced clinical trial stages.
Journal ArticleDOI
Molecular Biomarkers in Multiple Sclerosis and Its Related Disorders: A Critical Review.
Maryam Gul,Amirhossein Azari Jafari,Muffaqam Shah,Seyyedmohammadsadeq Mirmoeeni,Safee Ullah Haider,Sadia Moinuddin,Ammar Chaudhry +6 more
TL;DR: Based on numerous recent clinical and experimental studies, it is demonstrated that several molecular biomarkers could very well aid in differentiating MS from its related disorders.
Book ChapterDOI
Neuromyelitis optica, aquaporin-4 antibodies, and neuroendocrine disorders
Raffaele Iorio,Claudia Papi +1 more
TL;DR: In this article, the involvement of hypothalamus and circumventricular organs in AQP4 autoimmunity was investigated in NMOSD patients, and the authors found that AQP 4-IgG expression is concentrated in the circumventricular organ and in the hypothalamus.
Journal ArticleDOI
Symptomatic and restorative therapies in neuromyelitis optica spectrum disorders.
Hesham Abboud,Andrea Salazar-Camelo,Naveen George,Sarah M. Planchon,Marcelo Matiello,Maureen A. Mealy,Andrew D. Goodman +6 more
TL;DR: Neuromyelitis optica spectrum disorders (NMOSD) are a group of autoimmune inflammatory conditions that primarily target the optic nerves, spinal cord, brainstem, and occasionally the cerebrum as mentioned in this paper.
Journal ArticleDOI
Frequency of diencephalic syndrome in NMOSD
TL;DR: In this paper, the frequency of diencephalic involvement in NMOSD patients was investigated and the associated characteristics in patients presenting such symptoms were described in patients who visited Isfahan Multiple Sclerosis Center from January 2013 to February 2020.
References
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Journal ArticleDOI
International consensus diagnostic criteria for neuromyelitis optica spectrum disorders
Dean M. Wingerchuk,Brenda Banwell,Jeffrey Bennett,Philippe Cabre,William M. Carroll,Tanuja Chitnis,Jérôme De Seze,Kazuo Fujihara,Benjamin Greenberg,Anu Jacob,Sven Jarius,Marco Aurélio Lana-Peixoto,Michael J. Levy,Jack H. Simon,Silvia Tenembaum,Anthony Traboulsee,Patrick Waters,Kay E. Wellik,Brian G. Weinshenker +18 more
TL;DR: The International Panel for NMO Diagnosis (IPND) was convened to develop revised diagnostic criteria using systematic literature reviews and electronic surveys to facilitate consensus and achieved consensus on pediatric NMOSD diagnosis and the concepts of monophasicNMOSD and opticospinal MS.
Journal ArticleDOI
International classification of sleep disorders-third edition: highlights and modifications.
TL;DR: Significant modifications have been made to the nosology of insomnia, narcolepsy, and parasomnias in the recently released third edition of the International Classification of Sleep Disorders.
Journal ArticleDOI
A brainstem inflammatory lesion causing REM sleep behavior disorder and sleepwalking (parasomnia overlap disorder).
Nadège Limousin,Caroline Dehais,Olivier Gout,Françoise Héran,Delphine Oudiette,Isabelle Arnulf +5 more
TL;DR: A 40-year-old woman with no prior parasomnia developed an acute inflammatory rhombencephalitis with multiple cranial nerve palsies and cerebellar ataxia, followed by myelitis 6 months later, and by an intracranial thrombophlebitis 1 month after, which could be responsible for the parasomnia overlap disorder.
Journal ArticleDOI
Narcolepsy as an initial manifestation of neuromyelitis optica with anti-aquaporin-4 antibody.
Toru Baba,Ichiro Nakashima,Takashi Kanbayashi,Masatoshi Konno,Toshiyuki Takahashi,Kazuo Fujihara,Tatsuro Misu,Atsushi Takeda,Yusei Shiga,Hiromasa Ogawa,Yasuto Itoyama +10 more
TL;DR: A case of NMO with anti-AQP4 antibody, whose initial manifestation was narcolepsy and marked decrease of CSF hypocretin level is reported.
Journal ArticleDOI
A patient with anti-aquaporin 4 antibody presenting hypersomnolence as the initial symptom and symmetrical hypothalamic lesions.
Kentaro Deguchi,Syoichiro Kono,Shoko Deguchi,Nobutoshi Morimoto,Masami Ikeda,Tomoko Kurata,Yoshio Ikeda,Tohru Matsuura,Takashi Kanbayashi,Toshiyuki Takahashi,Koji Abe +10 more
TL;DR: The present case suggests a close relationship between the positive serum anti-AQP4 antibody and symmetrical hypothalamic lesions with hypersomnolence and without optic /spinal lesion, which is improved by steroid treatment.