Journal ArticleDOI
Selective Cognitive Impairment Following Traumatic Brain Injury in Rats
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The results of this experiment revealed that performance of the passive avoidance and the constant-start version of the Morris water maze were not impaired by fluid percussion TBI.About:
This article is published in Behavioural Brain Research.The article was published on 1993-12-31. It has received 145 citations till now. The article focuses on the topics: Morris water navigation task.read more
Citations
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Journal ArticleDOI
Animal Models of Head Trauma
TL;DR: A search continues for new animal models, which would more closely mimic the highly heterogeneous nature of human TBI, and address key factors in treatment optimization.
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Motor and cognitive function evaluation following experimental traumatic brain injury
TL;DR: The goal of this review is to describe and evaluate the tests employed to assess functional outcome after TBI and to overview aspects of cognitive, sensory, and motor function that may be suitable targets for therapeutic intervention.
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Spatial and temporal characteristics of neurodegeneration after controlled cortical impact in mice: more than a focal brain injury.
Edward D. Hall,Patrick G. Sullivan,Tonya R. Gibson,Krissi M. Pavel,Brian M. Thompson,Stephen W. Scheff +5 more
TL;DR: The extent of ipsilateral and contralateral neurodegeneration provides a more complete anatomical correlate for the cognitive and motor dysfunction seen in this paradigm and suggests that visual disturbances are also likely to be involved in the post-CCI neurological deficits.
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Novel pharmacologic strategies in the treatment of experimental traumatic brain injury : 1998
TL;DR: A compendium of recent studies suggesting that modification of post-traumatic neurochemical and cellular events with targeted pharmacotherapy can promote functional recovery following traumatic injury to the central nervous system is presented.
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Traumatic brain injury induced cell proliferation in the adult mammalian central nervous system.
TL;DR: The studies showed that the total number of proliferating cells was significantly increased in the injury group for both the SVZ and the hippocampus, and should lead to a new generation of studies aimed at enhancing the neuronal proliferative response.
References
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Place navigation impaired in rats with hippocampal lesions.
TL;DR: It is reported that, in addition to a spatial discrimination impairment, total hippocampal lesions also cause a profound and lasting placenavigational impairment that can be dissociated from correlated motor, motivational and reinforcement aspects of the procedure.
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Temporal profile of neuronal damage in a model of transient forebrain ischemia.
TL;DR: The unique delay in onset of ischemic cell change and the protracte increase in its incidence between 24 and 72 hours could reflect either delayed‐appearance of isChemic change in previously killed neurons or a delayed insult that continued to jeopardize compromised but otherwise viable neurons during the postischemic period.
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Limbic seizure and brain damage produced by kainic acid: Mechanisms and relevance to human temporal lobe epilepsy
TL;DR: This work has shown that kainate-like endotoxins pose a novel threat to the integrity of the immune system through their role as a “spatially aggregating substance” in the response of epilepsy.
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A fluid percussion model of experimental brain injury in the rat
C. E. Dixon,Bruce G. Lyeth,John T. Povlishock,Robert L. Findling,Robert J. Hamm,Anthony Marmarou,H. F. Young,Ronald L. Hayes +7 more
TL;DR: The data demonstrate that fluid percussion injury in the rat reproduces many of the features of head injury observed in other models and species, and could represent a useful experimental approach to studies of pathological changes similar to those seen in human head injury.
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Configural association theory: The role of the hippocampal formation in learning, memory, and amnesia.
TL;DR: How the theory can be applied to explain a wide range of impairments that have been observed when learning and memory tasks have been employed to assess the effect of hippocampal formation damage is illustrated.