Journal ArticleDOI
Selective inhibition of cyclooxygenase-2 by C-phycocyanin, a biliprotein from Spirulina platensis.
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TLDR
The present study points out that the hepatoprotective, anti-inflammatory, and anti-arthritic properties of phycocyanin reported in the literature may be due, in part, to its selective COX-2 inhibitory property, although its ability to efficiently scavenge free radicals and effectively inhibit lipid peroxidation may also be involved.About:
This article is published in Biochemical and Biophysical Research Communications.The article was published on 2000-11-02. It has received 277 citations till now. The article focuses on the topics: Phycocyanin & Phycocyanobilin.read more
Citations
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Sub- and supercritical fluid extraction of functional ingredients from different natural sources: Plants, food-by-products, algae and microalgae: A review
TL;DR: In this article, the authors provide an updated overview on the principal applications of two clean processes, supercritical fluid extraction and subcritical water extraction, used to isolate natural products from different raw materials, such as plants, food by-products, algae and microalgae.
Journal ArticleDOI
Bioactive compounds from cyanobacteria and microalgae: an overview.
TL;DR: Cyanobacteria (blue-green algae) are photosynthetic prokaryotes used as food by humans and are reported to be a source of fine chemicals, renewable fuel and bioactive compounds.
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The antioxidant, immunomodulatory, and anti-inflammatory activities of Spirulina: an overview
TL;DR: Clinical trials show that Spirulina prevents skeletal muscle damage under conditions of exercise-induced oxidative stress and can stimulate the production of antibodies and up- or downregulate the expression of cytokine-encoding genes to induce immunomodulatory and anti-inflammatory responses.
Journal ArticleDOI
Resveratrol analogues as selective cyclooxygenase-2 inhibitors: synthesis and structure-activity relationship.
Marek Murias,Norbert Handler,Thomas Erker,Karin Pleban,Gerhard F. Ecker,Philipp Saiko,Thomas Szekeres,Walter Jäger +7 more
TL;DR: Docking studies on both COX-1 andCOX-2 protein structures revealed that hydroxylated but not methoxylated resveratrol analogues are able to bind to the previously identified binding sites of the enzymes.
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Scavenging of peroxynitrite by phycocyanin and phycocyanobilin from Spirulina platensis: protection against oxidative damage to DNA.
Vadiraja B. Bhat,K.M. Madyastha +1 more
TL;DR: In this paper, the authors have demonstrated that phycocyanin, a biliprotein from spirulina platensis and its chromophore, phyCocyanobilin (PCB), efficiently scavenges ONOO −, a potent physiological inorganic toxin.
References
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Journal ArticleDOI
A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding
TL;DR: This assay is very reproducible and rapid with the dye binding process virtually complete in approximately 2 min with good color stability for 1 hr with little or no interference from cations such as sodium or potassium nor from carbohydrates such as sucrose.
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Inhibition of prostaglandin synthesis as a mechanism of action for aspirin-like drugs
TL;DR: Experiments with guinea-pig lung suggest that some of the therapeutic effects of sodium salicylate and aspirin-like drugs are due to inhibition of the synthesis of prostaglandins.
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Cyclooxygenases 1 and 2
TL;DR: The discovery ofCOX-2 has made possible the design of drugs that reduce inflammation without removing the protective PGs in the stomach and kidney made by COX-1, which may not only be anti-inflammatory but may also be active in colon cancer and Alzheimer's disease.
Journal ArticleDOI
Prostaglandin Endoperoxide H Synthases (Cyclooxygenases)-1 and −2
TL;DR: This review compares and contrast PGHS-1 and -2 in the context of the regulation of expression of the two enzymes, the mechanisms of enzyme catalysis, and the biological significance of having two PGHSs.
Journal ArticleDOI
Expression of a mitogen-responsive gene encoding prostaglandin synthase is regulated by mrna splicing
TL;DR: A distinguishing feature of src-inducible prostaglandin synthase mRNA is its low abundance in nonproliferating chicken embryo fibroblasts and its relatively high abundance in src-transformed cells.
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C-Phycocyanin: A Potent Peroxyl Radical Scavenger in Vivo and in Vitro
Vadiraja B. Bhat,K.M. Madyastha +1 more