Journal ArticleDOI
Selective Oxidation with N-Bromosuccinimide. II. Cholestane-3β,5α,6β-triol
Reads0
Chats0
About:
This article is published in Journal of the American Chemical Society.The article was published on 1949-12-01. It has received 150 citations till now.read more
Citations
More filters
Journal ArticleDOI
A sensitive and specific LC-MS/MS method for rapid diagnosis of Niemann-Pick C1 disease from human plasma
Xuntian Jiang,Rohini Sidhu,Forbes D. Porter,Nicole M. Yanjanin,Anneliese O. Speak,Danielle Taylor te Vruchte,Frances M. Platt,Hideji Fujiwara,David E. Scherrer,Jessie Zhang,Dennis J. Dietzen,Jean E. Schaffer,Daniel S. Ory +12 more
TL;DR: The development of a sensitive and specific LC-MS/MS method for quantifying 3β,5α,6β-triol and 7-KC human plasma after derivatization with N,N-dimethylglycine is described, offering for the first time a noninvasive, rapid, and highly sensitive method for diagnosis of NPC1 disease.
Journal ArticleDOI
Angiotoxicity of oxygenated sterols and possible precursors
Hideshige Imai,Nicholas T. Werthessen,Vinayakam Subramanyam,Philip W. LeQuesne,A. H. Soloway,Masayoshi Kanisawa +5 more
TL;DR: In this paper, cell death, inflammation, and repair in rabbits' aortas and pulmonary arteries were observed at 3-, 7-, and 10-day periods after the intravenous injection of oxygenated sterols.
Journal ArticleDOI
Homocysteine induced arteriosclerosis-like alterations of the aorta in normotensive and hypertensive rats following application of high doses of methionine
TL;DR: In addition to the disorder of fat and carbohydrate metabolism, disturbed protein metabolism is of decisive importance as a risk factor for coronary and other vascular diseases.
Journal ArticleDOI
Formation and metabolism in vitro of 5,6-epoxides of cholesterol and beta-sitosterol.
Leif Aringer,Peter Eneroth +1 more
TL;DR: The formation of 5alpha,6alpha- and 5beta,6beta-epoxides of cholesterol and beta-sitosterol in rat liver subcellular fractions has been studied and it is shown that the epoxidation seems to occur only in connection with the nonspecific tissue oxidation of the sterols.
Journal ArticleDOI
Formation of Biologically Active Oxysterols during Ozonolysis of Cholesterol Present in Lung Surfactant
TL;DR: Both 5β,6β-epoxycholesterol and cholestan-6-oxo-3β,5α-diol were shown to be cytotoxic to cultured 16-HBE cells, suggesting a possible mechanism for cytotoxicity is the ability of these oxysterols to inhibit isoprenoid-based cholesterol biosynthesis in these cells.
Related Papers (5)
Selective Oxidation with N-Bromosuccinimide. I. Cholic Acid
Formation and metabolism in vitro of 5,6-epoxides of cholesterol and beta-sitosterol.
Leif Aringer,Peter Eneroth +1 more