Journal ArticleDOI
Angiotoxicity of oxygenated sterols and possible precursors
Hideshige Imai,Nicholas T. Werthessen,Vinayakam Subramanyam,Philip W. LeQuesne,A. H. Soloway,Masayoshi Kanisawa +5 more
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TLDR
In this paper, cell death, inflammation, and repair in rabbits' aortas and pulmonary arteries were observed at 3-, 7-, and 10-day periods after the intravenous injection of oxygenated sterols.Abstract:
Cell death, inflammation, and repair in rabbits' aortas and pulmonary arteries were observed at 3-, 7-, and 10-day periods after the intravenous injection of oxygenated sterols. Thus, oxygenated sterols, not cholesterol, may play the primary role in arterial wall injury and lesion development.read more
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Dietary carcinogens and anticarcinogens Oxygen radicals and degenerative diseases
TL;DR: Dietary intake of natural antioxidants could be an important aspect of the body's defense mechanism against these agents of cancer and other age-related diseases.
Journal ArticleDOI
Oxygen Radicals and Human Disease
Carroll E. Cross,Barry Halliwell,Edward T. Borish,William A. Pryor,Bruce N. Ames,Robert L. Saul,Joe M. McCORD,Denham Harman +7 more
TL;DR: Attention is focused on cigarette smoke oxidants, ischemia-reperfusion-induced radical production, carcinogenesis, and aging, which may well provide a firm foundation for therapeutic breakthroughs in oxy-radical research.
Journal ArticleDOI
Oxysterols: modulators of cholesterol metabolism and other processes.
TL;DR: This review comprises a detailed and critical assessment of current knowledge regarding the formation, occurrence, metabolism, regulatory properties, and other activities of oxysterols in mammalian systems.
Journal ArticleDOI
Oxysterols and atherosclerosis
Andrew J. Brown,Wendy Jessup +1 more
TL;DR: There are a number of significant and quite widespread problems with current literature which preclude more than a tentative suggestion that oxysterol have a causal role in atherogenesis, and further studies are necessary to definitively determine the role of oxysterols in atherosclerosis.
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Biological effects of oxysterols: Current status
TL;DR: The authors find that OS deserve much more attention than cholesterol itself in terms of research activity but that unfortunately the reverse is true with regard to funding.
References
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Journal ArticleDOI
Biological activity of some oxygenated sterols
TL;DR: The ability of oxygenated sterols to inhibit sterol synthesis in cultured cells and the ineffectiveness of cholesterol under the same conditions suggest that feedback regulation of sterol biosynthesis may be brought about by an oxygenated steroid rather than by cholesterol.
Journal Article
Angiotoxicity and arteriosclerosis due to contaminants of USP-grade cholesterol.
TL;DR: The concentrate increased the frequency of dead aortic smooth muscle cells and induced focal intimal edema in the rabbit 24 hours after gavage and induced an increase in aggregate debris in 24 hours at 250 mg/kg but no increase in degenerated cells.