Selective sparing of human nucleus accumbens in aging and anoxia.
Ke-Wei Huang,Yan Zhao +1 more
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TLDR
Results show that accumbens was resistant to both aging and anoxia, the mechanism of which is discussed.Abstract:
OBJECTIVE To investigate the effects of aging and anoxia on the nucleus accumbens. METHODS The number of neurons in nucleus accumbens and caudate nucleus in 35 patients over 65 and 35 under 65 years, all without neurological or psychiatric disease were counted. RESULTS There was no statistically significant difference between the number of neurons in the accumbens in the two groups, but there was a decrease in the number of neurons in the elderly group. There was no reduction in volume of the neuronal nucleoli of the accumbens measured in 12 elderly patients compared to controls. These data suggest a sparing of the accumbens from changes associated with aging. There was relative preservation of the nucleus accumbens in 3 patients with anoxic encephalopathy. CONCLUSIONS These results show that accumbens was resistant to both aging and anoxia, the mechanism of which is discussed.read more
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Gray matter blood flow change is unevenly distributed during moderate isocapnic hypoxia in humans
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Effect of acute hypoxia on blood flow in vertebral and internal carotid arteries
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TL;DR: During hypoxia, internal carotid artery flow is maintained despite a reduction in (end‐tidal) carbon dioxide tension, while vertebral artery blood flow increases.
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Aging in nucleus accumbens and its impact on alcohol use disorders
TL;DR: In this article , a review discusses the available data to try to understand how aging affects the nucleus accumbens (nAc) and its neurochemical response to alcohol, and the data show that there is little information on the effects of ethanol in aged mice and rats, and that many studies had considered 2-3month-old mice as adults, which need to be reconsidered since more recent literature defines 6 months as young adults and >18 months as an older mouse.
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Experimental Study of NADPH-Diaphorase Positive Neurons in Nucleus Accumbens of Rats
Yan Zhao,Ke-Wei Huang +1 more
TL;DR: Positive neurons in the nucleus accumbens were more abundant than in the caudate and putamen and related to the presence of a large number of NADPH-diaphorase positive neurons.
during moderate isocapnic hypoxia in humans Gray matter blood flow change is unevenly distributed
Andrew P. Binks,Vincent J. Cunningham,Lewis Adams,Robert B. Banzett,Janine Cooper,Michael P. W. Grocott,Daniel Martin,J Stocks,Aidan Laverty,Emma Fettes,Romola S. Bucks,P. N. Ainslie,Christopher K. Willie,Kurt J. Smith,Trevor A. Day,L. A. Ray,Nicola S Lewis,Akke Bakker,David B. MacLeod,Nia C. S. Lewis,Laura Messinger,Brad Monteleone,Philip N. Ainslie +22 more
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