Journal ArticleDOI
Self-cleavage of RNA in the replication of small pathogens of plants and animals
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TLDR
The ability of certain small, circular, pathogenic RNAs of plants and animals to self-cleave at specific sites in vitro in the complete absence of protein most likely plays a central role in their replication in vivo by a rolling circle mechanism.About:
This article is published in Trends in Biochemical Sciences.The article was published on 1989-11-01. It has received 159 citations till now. The article focuses on the topics: RNA & RNA-dependent RNA polymerase.read more
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Ribozymes as potential anti-HIV-1 therapeutic agents.
Nava Sarver,Edouard M. Cantin,Pairoj Chang,Pairoj Chang,John A. Zaia,Paula A. Ladne,Delilah A. Stephens,John J. Rossi +7 more
TL;DR: The present study shows precise cleavage of human immunodeficiency virus type 1 (HIV-1) sequences in a cell-free system by hammerhead ribozymes, suggesting the feasibility of developing Ribozymes as therapeutic agents against human pathogens such as HIV-1.
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Specific regulation of gene expression by antisense, sense and antigene nucleic acids.
TL;DR: The regula t ion of gene express ion in l iving organisms rests main ly upon the recogniT ion of nucleic acid base sequences by pro te ins, but nucleic acids can also p lay a role.
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Ribozymes: a distinct class of metalloenzymes
TL;DR: The exploitation of variable metal geometry and reactivity has expanded ribozyme chemistry and has facilitated the application of in vitro selection for the creation of novel ribozymes.
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Visualizing the higher order folding of a catalytic RNA molecule.
TL;DR: Results directly demonstrate that divalent metal ions participate in general folding of the ribozyme tertiary structure, and further indicate a more specific involvement of Mg(II) in catalysis.
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A site-specific self-cleavage reaction performed by a novel RNA in neurospora mitochondria
TL;DR: A novel DNA and RNA found in the mitochondria of the Varkud-1c natural isolate of Neurospora lacks a hammer-head structure or substantial sequence similarity to any other self-cleaving RNA, suggesting that the RNA structure involved in cleavage may be different from those in previously characterized catalytic RNA.
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Simple RNA enzymes with new and highly specific endoribonuclease activities
Jim Haseloff,W. L. Gerlach +1 more
TL;DR: In vitro mutagenesis of sequences required for the self-catalysed cleavage of a plant virus satellite RNA has allowed definition of an RNA segment with endoribonuclease activity.
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Nonviral retroposons: genes, pseudogenes, and transposable elements generated by the reverse flow of genetic information
TL;DR: The Viral Supeifamily, The Viral Superfamily, and The Nonviral Superfamily: A Functional Semiprocessed Retrogene are presented.
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A small catalytic oligoribonucleotide
TL;DR: A 19-nucleotide RNA fragment can cause rapid, highly specific cleavage of a 24-nuclear RNA fragment under physiological conditions.
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Self-cleavage of plus and minus RNAs of a virusoid and a structural model for the active sites
TL;DR: This work synthesizes plus and minus partial-length RNAs of the 324-nucleotide virusoid from lucerne transient streak virus in vitro, indicating that unit-length plus RNA is generated by specific cleavage reactions.
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Biological catalysis by RNA.
Thomas R. Cech,Brenda L. Bass +1 more
TL;DR: Comparing RNA and PROTEINS AS BIOLOGICAL CATALYSTS, RNA SPLICING, and REPLICATION of Plant INFECTIOUS AGENTS are recommended.