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Journal ArticleDOI

Sensory Experiences of Gilles de la Tourette Syndrome

Joseph Bliss
- 01 Dec 1980 - 
- Vol. 37, Iss: 12, pp 1343-1347
TLDR
A patient with a 62-year history of Gilles de la Tourette syndrome describes 35 years of self-observation of the subjective events that precede, accompany, and follow the occurrence of symptomatic movements and sounds.
Abstract
• A patient with a 62-year history of Gilles de la Tourette syndrome describes 35 years of self-observation of the subjective events that precede, accompany, and follow the occurrence of symptomatic movements and sounds. Bodily sites become sensitized, and the movements (however bizarre) are intentional acts aimed at satisfying and eliminating unfulfilled sensations and urges. Sensory impressions may be projected onto other persons, objects, or imagined objects; these phantom sensations also demand discharge through actions. With vigilance and self-observation, barely emergent sensations can be recognized and controlled temporarily through substitution or extinction. The need to cope with rampant sensations and their consequences on one hand and current affairs on the other creates a dual citizenship within the person.

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Citations
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Journal ArticleDOI

Tourette's syndrome.

TL;DR: A new perspective is offered on the understanding of the pathogenesis of Tourette's syndrome and on principles for treatment of patients with this disorder.
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Premonitory Urges in Tourette's Syndrome

TL;DR: The results suggest that premonitory urges may be commonplace in adolescent and adult subjects with tic disorders and challenge the conventional wisdom that tic behaviors are wholly involuntary in character.
Journal ArticleDOI

Sensorimotor gating in boys with Tourette's syndrome and ADHD: Preliminary results

TL;DR: These findings, together with other converging lines of evidence, suggest that deficient pallidal inhibition may be etiologically related to tic and movement disorders.
Journal ArticleDOI

Decreased motor inhibition in Tourette's disorder: evidence from transcranial magnetic stimulation.

TL;DR: Findings are consistent with the hypothesis that tics in Tourette's disorder originate either from a primarily subcortical disorder affecting the motor cortex through disinhibited afferent signals or from impaired inhibition directly at the level of the Motor cortex or both.
Journal ArticleDOI

The Gilles de la Tourette syndrome: the current status.

TL;DR: A review briefly considers early descriptions of GTS as well as current research, highlighting the areas of agreement and controversy.
References
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TL;DR: It is concluded that systemically administered clonidine inhibits the firing of brain NE neurons by acting directly upon adrenergic receptors located on or near the soma of these neurons but that the concomitant inhibition of 5-HT neurons is an indirect effect (possibly secondary to an impairment in noracrenergic transmission).
Journal ArticleDOI

II. New evidence for a locus coeruleus-norepinephrine connection with anxiety

TL;DR: Data from studies of the function of the nucleus locus coereleus in non-human primates are presented in the context of recent anatomical, physiological, pharmacological, and animal behavioral experiments, suggesting implications for the treatment of anxiety, drug addictions, pain, and psychosomatic diseases.
Journal ArticleDOI

Neurochemical modulation of sensory-motor reactivity: acoustic and tactile startle reflexes.

TL;DR: The present review argues that the startle reflex is particularly well suited as a model system to analyze how drugs alter stimulus reactivity and reflex excitability and that drugs or lesions that are thought to alter neurochemical transmitter systems affect acoustic and/or tactile startle.
Journal ArticleDOI

Gilles de la tourette syndrome: Clinical and family study of 50 cases

TL;DR: Among the 50 patients with Tourette syndrome there was a high frequency of sleep disturbance, learning disability, self‐destructive behavior, inappropriate sexual activity, and antisocial behavior, and the frequency of side effects caused by haloperidol.
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