Serum 25-Hydroxyvitamin D Concentrations and Incidence of Age-Related Macular Degeneration: The Atherosclerosis Risk in Communities Study
Amy E. Millen,Jing Nie,Julie A. Mares,Pamela L. Lutsey,Michael J. LaMonte,Stacy M. Meuer,Michelle W. Sahli,Chris Andrews,Barbara E.K. Klein,Ronald Klein +9 more
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TLDR
High 25(OH)D concentrations, approximately >70 nM, may be associated with decreased odds of incident early AMD, suggesting these associations may be biased by loss to follow-up and sampling for retinal photographs at visit 5.Abstract:
Purpose To investigate the association between serum 25-hydroxyvitamin D (25[OH]D) concentrations at visit 2 (1990-1992) and the 18-year incidence of age-related macular degeneration (AMD) between visit 3 (1993-1995) and visit 5 (2011-2013). Methods This prospective analysis was conducted in a subset of participants (n = 1225) from the Atherosclerosis Risk in Communities Study. We evaluated the incidence of any, early, and late AMD from visit 3 to 5. The 25(OH)D concentrations were assessed in 2012-2013 by using stored serum from visit 2. Retinal fundus photographs taken at both visits were graded side by side to determine the incidence of AMD. Logistic regression was used to estimate the odds ratios (ORs) and 95% confidence intervals (CIs) for incident AMD outcomes during 18 years of follow-up (1993-1995 to 2011-2013) by tertile of 25(OH)D adjusted for age, race, and smoking status. P for linear trend was estimated by using continuous 25(OH)D concentrations. Sensitivity analyses applied inverse probability weights to account for selection to have eye photographs, death, and loss to follow-up. Results There was a decreased odds of any incident AMD (n = 139) and large, soft drusen (n = 80) in 25(OH)D tertile 3 versus 1, with OR (95% CI) = 0.57 (0.36-0.90), P trend = 0.11 and with 0.52 (0.28-0.93), P trend = 0.18, respectively. Applying sampling weights attenuated these results to 0.66 (0.38-1.16), P trend = 0.32 (any incident AMD) and 0.54 (0.27-1.09), P trend = 0.36 (large, soft drusen), respectively, suggesting these associations may be biased by loss to follow-up and sampling for retinal photographs at visit 5. No statistically significant results were observed with pigmentary abnormalities (n = 46) or incident late AMD (n = 26). Conclusions High 25(OH)D concentrations, approximately >70 nM, may be associated with decreased odds of incident early AMD.read more
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Vitamin D and Ocular Diseases: A Systematic Review
Hei-Nga Chan,Xiu Juan Zhang,Xiang-Tian Ling,Christine H T Bui,Yu Meng Wang,Patrick Ip,Wai Kit Chu,Li-Jia Chen,Clement C Y Tham,Jason C. S. Yam,Chi Pui Pang +10 more
TL;DR: A systematic review of recent findings on the association between vitamin D and different ocular diseases, including myopia, age-related macular degeneration, glaucoma, diabetic retinopathy, dry eye syndrome, thyroid eye disease, uveitis, retinoblastoma, cataract, and others, from epidemiological, clinical and basic studies is provided.
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Effect of Vitamin D and ω-3 Fatty Acid Supplementation on Risk of Age-Related Macular Degeneration: An Ancillary Study of the VITAL Randomized Clinical Trial.
William G. Christen,Nancy R. Cook,Nancy R. Cook,JoAnn E. Manson,JoAnn E. Manson,Julie E. Buring,Julie E. Buring,Daniel I. Chasman,Daniel I. Chasman,I-Min Lee,Vadim Bubes,Chunying Li,Margarette Haubourg,Debra A. Schaumberg +13 more
TL;DR: Neither vitamin D3 nor marine ω-3 fatty acid supplementation had a significant overall effect on AMD incidence or progression.
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Serum vitamin D and age-related macular degeneration: systematic review and meta-analysis
TL;DR: There is no clear evidence of a definitive association between serum 25(OH)D and AMD risk, mainly due to heterogeneity in studies procedures and lack of longitudinal designs.
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Anti-Inflammatory and Anti-Oxidative Synergistic Effect of Vitamin D and Nutritional Complex on Retinal Pigment Epithelial and Endothelial Cell Lines against Age-Related Macular Degeneration.
Maria Hernandez,Sergio Recalde,Jorge González-Zamora,Valentina Bilbao-Malavé,Manuel Saenz de Viteri,Jaione Bezunartea,Maite Moreno-Orduña,Idoia Belza,Jesús Barrio-Barrio,Patricia Fernandez-Robredo,Alfredo García-Layana +10 more
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