Journal ArticleDOI
Seven Ways to Preserve the Miracle of Antibiotics
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TLDR
A number of interventions are proposed that could make a large difference in reducing antibiotic abuse in people and animals and placing great emphasis on antibiotic stewardship.Abstract:
Antibiotic resistance is a well-acknowledged crisis with no clearly defined comprehensive, national corrective plan. We propose a number of interventions that, collectively, could make a large difference. These include collection of data to inform decisions, efforts to reduce antibiotic abuse in people and animals, great emphasis on antibiotic stewardship, performance incentives, optimal use of newer diagnostics, better support for clinical and basic resistance-related research, and novel methods to foster new antibiotic development.read more
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The Antibiotic Resistance Crisis: Part 1: Causes and Threats
TL;DR: Decades after the first patients were treated with antibiotics, bacterial infections have again become a threat because of the rapid emergence of resistant bacteria-a crisis attributed to abuse of these medications and a lack of new drug development.
Journal ArticleDOI
Antibiotic resistance: a rundown of a global crisis.
Bilal Aslam,Wei Wang,Muhammad Imran Arshad,Mohsin Khurshid,Saima Muzammil,Muhammad Hidayat Rasool,Muhammad Atif Nisar,Ruman Farooq Alvi,Muhammad Aamir Aslam,Muhammad Usman Qamar,Muhammad Khalid Farooq Salamat,Zulqarnain Baloch +11 more
TL;DR: Progressive alternate approaches including probiotics, antibodies, and vaccines have shown promising results in trials that suggest the role of these alternatives as preventive or adjunct therapies in future.
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Antibiotics in the aquatic environments: A review of the European scenario.
Isabel Carvalho,Lúcia Santos +1 more
TL;DR: This literature review summarizes the state of knowledge on the occurrence of antibiotics in the different aqueous environmental systems across the Europe, as reported since 2000 and provides an improved understanding on aquatic pollution by antibiotics to outline the European scenario.
Journal ArticleDOI
Antimicrobial Resistance: Implications and Costs.
TL;DR: The literature review, which included articles published after the year 2012, indicated that the multifactorial threat of antimicrobial resistance has resulted in different complex issues affecting countries across the globe.
References
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Journal ArticleDOI
An intervention to decrease catheter-related bloodstream infections in the ICU
Peter J. Pronovost,Dale M. Needham,Sean M. Berenholtz,David J. Sinopoli,Haitao Chu,Sara E. Cosgrove,Bryan Sexton,Robert C. Hyzy,Robert J. Welsh,Gary Roth,Joseph Bander,John P. Kepros,Christine A. Goeschel +12 more
TL;DR: An evidence-based intervention resulted in a large and sustained reduction (up to 66%) in rates of catheter-related bloodstream infection that was maintained throughout the 18-month study period.
Journal ArticleDOI
Food Animals and Antimicrobials: Impacts on Human Health
Bonnie Marshall,Stuart B. Levy +1 more
TL;DR: The substantial and expanding volume of evidence reporting animal-to-human spread of resistant bacteria, including that arising from use of NTAs, supports eliminating NTA use in order to reduce the growing environmental load of resistance genes.
Journal ArticleDOI
Comparison of 8 vs 15 days of antibiotic therapy for ventilator-associated pneumonia in adults: a randomized trial.
Jean Chastre,Michel Wolff,Jean-Yves Fagon,Sylvie Chevret,Franck Thomas,Delphine Wermert,Eva Clementi,Jesus Gonzalez,Dominique Jusserand,Pierre Asfar,Dominique Perrin,Fabienne Fieux,Sylvie Aubas +12 more
TL;DR: Although patients with VAP caused by nonfermenting gram-negative bacilli, including Pseudomonas aeruginosa, did not have more unfavorable outcomes when antimicrobial therapy lasted only 8 days, they did have a higher pulmonary infection-recurrence rate compared with those receiving 15 days of treatment.
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