Journal ArticleDOI
Signatures of natural selection in the human genome
TLDR
Signs of natural selection left in the authors' genome can be used to identify genes that might underlie variation in disease resistance or drug metabolism, but these signatures are confounded by population history and by variation in local recombination rates.Abstract:
During their dispersal from Africa, our ancestors were exposed to new environments and diseases Those who were better adapted to local conditions passed on their genes, including those conferring these benefits, with greater frequency This process of natural selection left signatures in our genome that can be used to identify genes that might underlie variation in disease resistance or drug metabolism These signatures are, however, confounded by population history and by variation in local recombination rates Although this complexity makes finding adaptive polymorphisms a challenge, recent discoveries are instructing us how and where to look for the signatures of selectionread more
Citations
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Journal Article
Statistical method for testing the neutral mutation hypothesis by DNA polymorphism.
TL;DR: It is suggested that the natural selection against large insertion/deletion is so weak that a large amount of variation is maintained in a population.
Journal ArticleDOI
DnaSP, DNA polymorphism analyses by the coalescent and other methods.
TL;DR: The present version of DnaSP introduces several new modules and features which, among other options, allow handling big data sets and conducting a large number of coalescent-based tests by Monte Carlo computer simulations.
Journal ArticleDOI
Molecular Signatures of Natural Selection
TL;DR: This review provides a nonmathematical description of the issues involved in detecting selection from DNA sequences and SNP data and is intended for readers who are not familiar with population genetic theory.
Journal ArticleDOI
The power and promise of population genomics: from genotyping to genome typing
TL;DR: The most useful contribution of the genomics model to population genetics will be improving inferences about population demography and evolutionary history.
Journal ArticleDOI
Positive Natural Selection in the Human Lineage
Pardis C. Sabeti,Stephen F. Schaffner,Ben Fry,Jason Lohmueller,Patrick Varilly,O. Shamovsky,Alejandro A. Palma,Tarjei S. Mikkelsen,David Altshuler,Eric S. Lander +9 more
TL;DR: The authors reviewed approaches to detect positive natural selection in humans, described results from recent analyses of genome-wide data, and discuss the prospects and challenges ahead as we expand our understanding of the role of natural selection on shaping the human genome.
References
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Book
Molecular Evolutionary Genetics
TL;DR: Recent developments of statistical methods in molecular phylogenetics are reviewed and it is shown that the mathematical foundations of these methods are not well established, but computer simulations and empirical data indicate that currently used methods produce reasonably good phylogenetic trees when a sufficiently large number of nucleotides or amino acids are used.
Journal Article
Statistical method for testing the neutral mutation hypothesis by DNA polymorphism.
TL;DR: It is suggested that the natural selection against large insertion/deletion is so weak that a large amount of variation is maintained in a population.
Journal ArticleDOI
Statistical method for testing the neutral mutation hypothesis by DNA polymorphism.
TL;DR: The relationship between the two estimates of genetic variation at the DNA level, namely the number of segregating sites and the average number of nucleotide differences estimated from pairwise comparison, is investigated in this article.
Book
The Neutral Theory of Molecular Evolution
TL;DR: The neutral theory as discussed by the authors states that the great majority of evolutionary changes at the molecular level are caused not by Darwinian selection but by random drift of selectively neutral mutants, which has caused controversy ever since.
Journal ArticleDOI
Statistical tests of neutrality of mutations against population growth, hitchhiking and background selection.
TL;DR: It is found that the polymorphic patterns in a DNA sample under logistic population growth and genetic hitchhiking are very similar and that one of the newly developed tests, Fs, is considerably more powerful than existing tests for rejecting the hypothesis of neutrality of mutations.