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Simple and Efficient Route to Synthesis of Functionalized Spiro(chromeno(2,3-d)pyrimidine-5,3'-indoline)- tetraones by K-10 as a Reusable Catalyst
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TLDR
In this paper, the reaction of isatin, barbituric acid, and cyclohexane-1,3-dione derivatives in the presence of K-10 as catalyst for 30 min was found to be a suitable and efficient method for the synthesis of spiro[chromeno[2,3]-pyrimidine-5,3'indoline]-tetraones.Abstract:
The reaction of isatin, barbituric acid, and cyclohexane-1,3-dione derivatives in the presence of K-10 as catalyst for 30 min was found to be a suitable and efficient method for the synthesis of spiro[chromeno[2,3-d]pyrimidine-5,3'indoline]-tetraones. This combination was done under ionic liquid media.read more
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One-pot, three-component synthesis of a library of spirooxindole-pyrimidines catalyzed by magnetic nanoparticle supported dodecyl benzenesulfonic acid in aqueous media.
TL;DR: Dodecyl benzenesulfonic acid functionalized silica-coated magnetic nanoparticles (γ-Fe2O3@SiO2-DDBSA) were readily prepared and identified as an efficient catalyst for the synthesis of a library of spirooxindole-pyrimidine derivatives by three-component condensation reaction of barbituric acids, isatins and cyclohexane-1,3-diones.
Journal ArticleDOI
Insights into Microwave Assisted Synthesis of Spiro-chromeno[2,3-d]pyrimidines Using PEG-OSO3H Catalyst: DFT study and their antiproliferative activity
S. G. Patel,Paras Patel,Dipti Upadhyay,Adrián Puerta,Apoorva Malik,Nagesh Kumar Kandukuri,Rakesh Sharma,José M. Padrón,Hiten M. Patel +8 more
TL;DR: In this article , an environmentally benign green approach for the synthesis of new spiro-chromeno[2,3-d]pyrimidines was established, which is notable for its eco-friendly polymer catalyst, rapid metal-free synthesis, easy workup, higher yield, no need for column chromatographic purification and outstanding green credential parameters of the process.
References
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Book
Ionic Liquids in Synthesis
Peter Wasserscheid,Tom Welton +1 more
TL;DR: The early years of Ionic liquid production were covered in this article, where a new generation of soluble supports for Supported Organic Synthesis (SPOS) was proposed. But this support was not applied to the task-specific Ionic liquids.