Journal ArticleDOI
Simultaneous stereoselective 4-amination with cyclic secondary amines and 2-O-deacetylation of peracetylated sialic acid derivatives
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TLDR
In this paper, cyclic secondary amines in pyridine at room temperature for 24h afforded unusual products (2a-g). Related experiments were carried out to explain the formation of 4amination and 2-O-deacetylation of peracetylated sialic acid derivatives.About:
This article is published in Tetrahedron Letters.The article was published on 2007-06-04. It has received 12 citations till now. The article focuses on the topics: Neuraminidase & Sialic acid.read more
Citations
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Journal ArticleDOI
Synthetic Approaches to the Neuraminidase Inhibitors Zanamivir (Relenza) and Oseltamivir Phosphate (Tamiflu) for the Treatment of Influenza
TL;DR: There is a growing concern that a worldwide pandemic will inevitably happen within the next few years.
Journal ArticleDOI
Influenza Neuraminidase Inhibitors: Synthetic Approaches, Derivatives and Biological Activity
TL;DR: These anti-influenza drugs have been used as templates for the development of new neuraminidase inhibitors through structure-activity relationship studies and the synthetic routes to these commercial drugs are reviewed.
Journal ArticleDOI
Discovery of Multifold Modified Sialosides as Human CD22/Siglec-2 Ligands with Nanomolar Activity on B-Cells
TL;DR: The observed increased Ca(2+) response corresponds to enhanced cell activation, providing an opportunity to therapeutically modulate B-lymphocyte responses, e.g., in immune deficiencies and infections.
Journal ArticleDOI
Synthesis of C-4-modified zanamivir analogs as neuraminidase inhibitors and their anti-AIV activities
Deju Ye,Woo Jin Shin,Ning Li,Wei Tang,Enguang Feng,Jian Li,Pei lan He,Jianping Zuo,Hanjo Kim,Ky Youb Nam,Weiliang Zhu,Baik Lin Seong,Kyoung Tai No,Hualiang Jiang,Hong Liu +14 more
TL;DR: Preliminary anti-avian influenza virus (AIV, H5N1) activities against infected MDCK cells were evaluated, and D5 exerts ∼58% protective against AIV infection, which was comparable to zanamivir.
Journal ArticleDOI
Highly α-Selective Synthesis of Sialyl Spirohydantoins by Regiospecific Domino Condensation/O→N Acyl Migration/N-Sialylation of Carbodiimides with Peracetylated Sialic Acid
TL;DR: A novel and efficient process for the synthesis of alpha-sialyl spirohydantoin analogues via one-pot sequential reaction involving various carbodiimides and peracetylated Neu5Ac is reported.
References
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Book
Mechanism and Theory in Organic Chemistry
TL;DR: The theory of pericyclic reactions was introduced in this article and applied to a wide range of applications in physical organic chemistry, such as addition and elimination reactions, nucleophilic substitution, and radical reactions.
Book ChapterDOI
Chemistry, Metabolism, and Biological Functions of Sialic Acids
TL;DR: This chapter discusses the chemistry, metabolism, and biological functions of sialic acids and the biosynthesis of N-acetylneuraminic acid is briefly reported and more attention is given to the enzyme reactions modifying this compound.
Journal ArticleDOI
Synthesis of complex carbohydrates and glycoconjugates: enzyme-based and programmable one-pot strategies.
Kathryn M. Koeller,Chi-Huey Wong +1 more
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Adventures in Carbohydrate Chemistry: New Synthetic Technologies, Chemical Synthesis, Molecular Design, and Chemical Biology
TL;DR: The field of carbohydrate chemistry has occupied the minds and hearts of many scientists for over a hundred years and, as we enter the twenty-first century, it continues to be both vigorous and challenging.
Related Papers (5)
On the specificity of neuraminidase. Synthesis of 5-N-acetyl-D-nonulosamine (5-acetamido-3,5-dideoxy-D-glycera- -D-galacto-nonulose) and 5-N-acetyl-D-neuraminamide (5-acetamido-3,5-dideoxy-D-glycero- -D-galacto-nonulosonamide) and their methyl - and benzyl -ketosides.
Reinhard Brossmer,Leif Holmquist +1 more