Journal ArticleDOI
Sinomenine versus NSAIDs for the treatment of rheumatoid arthritis: a systematic review and meta-analysis
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TLDR
SIN may be a valuable remedy to treat RA clinically, although current evidence needs to be further verified by more high-quality trials.Abstract:
Sinomenine (SIN), an alkaloid isolated from CAULIS SINOMENII, has been used in the treatment of rheumatoid arthritis (RA) clinically. This study aimed to systematically evaluate the efficacy and safety of SIN by a comparison between SIN and non-steroidal anti-inflammatory drugs (NSAIDs). Forty-three electronic databases were systematically searched. The quality of eligible trials was assessed by Jadad's scale. Revman 5.0 software was used for data syntheses and meta-analyses. The results showed that (i) of the 121 potential studies identified, 10 clinical trials involving 1185 patients met the inclusion criteria; (ii) improved patients and rheumatoid factor disappearance patients after SIN treatments were significantly more than those treated by NSAIDs ( P 0.05); and (iv) adverse events occurred less frequently in the digestive system during SIN treatment than during NSAID treatment ( P = 0.0003) but occurred more frequently in the dermatomucosal system with SIN treatment ( P = 0.03), while adverse events of the nervous system were similar for both treatments ( P = 0.31). In conclusion, SIN may be a valuable remedy to treat RA clinically, although current evidence needs to be further verified by more high-quality trials.read more
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Modulators of microglial activation and polarization after intracerebral haemorrhage.
TL;DR: Key studies on modulators of microglial activation and polarization after ICH are summarized, including M1-like and M2-like microglia phenotype markers, transcription factors and key signalling pathways, and the evidence that therapeutic approaches aimed at modulating microglian function might mitigate ICH injury and improve brain repair is presented.
Journal ArticleDOI
Sinomenine Inhibits the Progression of Rheumatoid Arthritis by Regulating the Secretion of Inflammatory Cytokines and Monocyte/Macrophage Subsets.
TL;DR: Data indicated that SIN regulates the secretion of multiple inflammatory cytokines and monocyte/macrophage subsets, thereby suppressing RA progression, and could be an alternative cost-effective anti-inflammatory agent for treating RA.
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Sinomenium acutum: a review of chemistry, pharmacology, pharmacokinetics, and clinical use
TL;DR: Previous studies strongly support its potential as an effective adaptogenic herbal remedy and there is no doubt that SA is being widely used now and will have extraordinary potential for the future.
Journal ArticleDOI
Intra-articular delivery of sinomenium encapsulated by chitosan microspheres and photo-crosslinked GelMA hydrogel ameliorates osteoarthritis by effectively regulating autophagy
TL;DR: The results demonstrate that injection of the combination of GelMA hydrogel and CM-SIN could be a promising strategy for treating patients with osteoarthritis.
Journal ArticleDOI
Biologically active isoquinoline alkaloids covering 2014–2018
Xiao-Fei Shang,Cheng-Jie Yang,Susan L. Morris-Natschke,Jun-Cai Li,Xiao-Dan Yin,Ying-Qian Liu,Xiao Guo,Peng Jingwen,Masuo Goto,Jiyu Zhang,Kuo Hsiung Lee,Kuo Hsiung Lee +11 more
TL;DR: Over 400 molecules with a broad range of bioactivities are reviewed, including antitumor, antidiabetic and its complications, antibacterial, antifungal, antiviral, antiparasitic, insecticidal, anti‐inflammatory, antioxidant, neuroprotective, and other activities.