Journal ArticleDOI
'Smart' polymers and what they could do in biotechnology and medicine.
Igor Yu. Galaev,Bo Mattiasson +1 more
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Stimulus-responsive or 'smart' polymers undergo strong conformational changes when only small changes in the environment occur, resulting in phase separation from aqueous solution or order-of-magnitude changes in hydrogel size.About:
This article is published in Trends in Biotechnology.The article was published on 1999-08-01. It has received 789 citations till now. The article focuses on the topics: Smart polymer.read more
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Synthetic molecular motors and mechanical machines.
TL;DR: The exciting successes in taming molecular-level movement thus far are outlined, the underlying principles that all experimental designs must follow, and the early progress made towards utilizing synthetic molecular structures to perform tasks using mechanical motion are highlighted.
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Stimuli-reponsive polymers and their bioconjugates
Eun Seok Gil,Samuel M. Hudson +1 more
TL;DR: In this article, the authors focused on temperature and pH responsive polymer systems and additionally the other stimuli-based responsive polymers will be assessed, which is more helpful to design new approaches because the basic concepts and mechanisms are systematically connected.
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Enzyme immobilization: The quest for optimum performance
TL;DR: Different methods for the immobilization of enzymes are critically reviewed, with emphasis on relatively recent developments, such as the use of novel supports, e.g., mesoporous silicas, hydrogels, and smart polymers, novel entrapment methods and cross-linked enzyme aggregates (CLEAs).
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Novel crosslinking methods to design hydrogels
Wim E. Hennink,C.F. van Nostrum +1 more
TL;DR: In this overview, different chemical and physical crosslinking methods used for the design of biodegradable hydrogels are summarized and discussed.
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Stimuli responsive polymers for biomedical applications
TL;DR: This critical review of polymers that can respond to external stimuli considers the types of stimulus response used in therapeutic applications and the main classes of responsive materials developed to date.
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Journal ArticleDOI
Mechanism of cell detachment from temperature-modulated, hydrophilic–hydrophobic polymer surfaces
TL;DR: Cell detachment was partially inhibited by sodium azide treatment, suggesting that cell metabolism directly affects cell detachment, and Morphological changes of the adherent cells during cell detachment experiments indicated further involvement of active cellular metabolic processes.
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Temperature-Responsive Chromatography Using Poly(N-isopropylacrylamide)-Modified Silica.
Hideko Kanazawa,Kazuo Yamamoto,Yoshikazu Matsushima,Nobuharu Takai,Akihiko Kikuchi,Yasuhisa Sakurai,Teruo Okano +6 more
TL;DR: A novel and useful new chromatography system in which surface properties and the resulting function of the HPLC stationary phase are controlled by externalTemperature changes should be effective in biological and biomedical separations of peptides and proteins using only aqueous mobile phases.
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Molecular Machines: How Motion and Other Functions of Living Organisms Can Result from Reversible Chemical Changes
TL;DR: These model proteins and the mechanism they reveal provide insight into the molecular basis for diverse biological functions; they are models for the molecular machines that comprise the living organism, and they provide a new class of materials for both medical and nonmedical applications.
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Dynamic contact angle measurement of temperature-responsive surface properties for poly(N-isopropylacrylamide) grafted surfaces
TL;DR: In this article, temperature modulation of surface properties for hydrophilic/hydrophobic changes using poly(N-isopropylacrylamide) (PIPAAm) was investigated.
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pH-Sensitive Gating by Conformational Change of a Polypeptide Brush Grafted onto a Porous Polymer Membrane
TL;DR: In this paper, a poly(glutamic acid)-grafted poly(tetrafluoroethylene) membrane was used to study the effects of pH and ionic strength on permeation rate.