Sociability and preference for social novelty in five inbred strains: an approach to assess autistic-like behavior in mice
Sheryl S. Moy,Jessica J. Nadler,Antonio Perez,Ryan P. Barbaro,Josephine M. Johns,Terry Magnuson,Terry Magnuson,Joseph Piven,Jacqueline N. Crawley,Jacqueline N. Crawley +9 more
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TLDR
A new standardized procedure to quantitate sociability and preference for social novelty in mice provides a method to assess tendencies for social avoidance in mouse models of autism.Abstract:
Deficits in social interaction are important early markers for autism and related neurodevelopmental disorders with strong genetic components. Standardized behavioral assays that measure the preference of mice for initiating social interactions with novel conspecifics would be of great value for mutant mouse models of autism. We developed a new procedure to assess sociability and the preference for social novelty in mice. To quantitate sociability, each mouse was scored on measures of exploration in a central habituated area, a side chamber containing an unfamiliar conspecific (stranger 1) in a wire cage, or an empty side chamber. In a secondary test, preference for social novelty was quantitated by presenting the test mouse with a choice between the first, now-familiar, conspecific (stranger 1) in one side chamber, and a second unfamiliar mouse (stranger 2) in the other side chamber. Parameters scored included time spent in each chamber and number of entries into the chambers. Five inbred strains of mice were tested, C57BL/6J, DBA/2J, FVB/NJ, A/J and B6129PF2/J hybrids. Four strains showed significant levels of sociability (spend- ing more time in the chamber containing stranger 1 than in the empty chamber) and a preference for social novelty (spending more time in the chamber containing stranger 2 than in the chamber containing the now-familiar stranger 1). These social preferences were observed in both male and female mice, and in juveniles and adults. The exception was A/J, a strain that demonstrated a preference for the central chamber. Results are discussed in terms of potential applications of the new methods, and the proper controls for the interpretation of social behavior data, including assays for health, relevant sensory abilities and motor functions. This new standardized procedure to quantitate sociability and preference for social novelty in mice provides a method to assess tendencies for social avoidance in mouse models of autism.read more
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Journal ArticleDOI
Neocortical excitation/inhibition balance in information processing and social dysfunction
Ofer Yizhar,Ofer Yizhar,Lief E. Fenno,Matthias Prigge,Franziska Schneider,Thomas J. Davidson,Daniel J. O’Shea,Vikaas S. Sohal,Vikaas S. Sohal,Inbal Goshen,Joel Finkelstein,Jeanne T. Paz,Katja Stehfest,Roman Fudim,Charu Ramakrishnan,John R. Huguenard,Peter Hegemann,Karl Deisseroth +17 more
TL;DR: In this article, the authors design and use several optogenetic tools to causally investigate the cellular E/I balance hypothesis in freely moving mammals, and explore the associated circuit physiology.
Neocortical excitation/inhibition balance in information processing and social
Lief E. Fenno,Matthias Prigge,Franziska Schneider,Thomas J. Davidson,Vikaas S. Sohal,Inbal Goshen,Joel Finkelstein,Jeanne T. Paz,Katja Stehfest,Roman Fudim,Charu Ramakrishnan,John R. Huguenard,Peter Hegemann,Karl Deisseroth +13 more
TL;DR: Elevation, but not reduction, of cellular E/I balance within the mouse medial prefrontal cortex was found to elicit a profound impairment in cellular information processing, associated with specific behavioural impairments and increased high-frequency power in the 30–80 Hz range, which have both been observed in clinical conditions in humans.
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Behavioural phenotyping assays for mouse models of autism
TL;DR: Robust phenotypes in mouse models hold great promise as translational tools for discovering effective treatments for components of autism spectrum disorders.
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Shank3 mutant mice display autistic-like behaviours and striatal dysfunction
João Peça,Catia Feliciano,Jonathan T. Ting,Wenting Wang,Michael F. Wells,Talaignair N. Venkatraman,Christopher D. Lascola,Zhanyan Fu,Zhanyan Fu,Guoping Feng,Guoping Feng,Guoping Feng +11 more
TL;DR: In this paper, Shank3 gene deletions were found to lead to repetitive grooming and impaired social interaction in mice with autism spectrum disorders (ASDs) and other non-syndromic ASDs.
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Natural Neural Projection Dynamics Underlying Social Behavior
Lisa A. Gunaydin,Logan Grosenick,Joel Finkelstein,Isaac Kauvar,Lief E. Fenno,Avishek Adhikari,Stephan Lammel,Julie J. Mirzabekov,Raag D. Airan,Kelly A. Zalocusky,Kay M. Tye,Polina Anikeeva,Robert C. Malenka,Karl Deisseroth,Karl Deisseroth +14 more
TL;DR: Fiber photometry was developed and applied to optically record natural neural activity in genetically and connectivity-defined projections to elucidate the real-time role of specified pathways in mammalian behavior and captures a fundamental and previously inaccessible dimension of mammalian circuit dynamics.
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