Journal ArticleDOI
The autism diagnostic observation schedule-generic: a standard measure of social and communication deficits associated with the spectrum of autism.
Catherine Lord,Susan Risi,Linda Lambrecht,Edwin H. Cook,Bennett L. Leventhal,Pamela C. DiLavore,Andrew Pickles,Michael Rutter +7 more
TLDR
Algorithm sensitivities and specificities for autism and PD DNOS relative to nonspectrum disorders were excellent, with moderate differentiation of autism from PDDNOS.Abstract:
The Autism Diagnostic Observation Schedule-Generic (ADOS-G) is a semistructured, standardized assessment of social interaction, communication, play, and imaginative use of materials for individuals suspected of having autism spectrum disorders. The observational schedule consists of four 30-minute modules, each designed to be administered to different individuals according to their level of expressive language. Psychometric data are presented for 223 children and adults with Autistic Disorder (autism), Pervasive Developmental Disorder Not Otherwise Specified (PDDNOS) or nonspectrum diagnoses. Within each module, diagnostic groups were equivalent on expressive language level. Results indicate substantial interrater and test-retest reliability for individual items, excellent interrater reliability within domains and excellent internal consistency. Comparisons of means indicated consistent differentiation of autism and PDDNOS from nonspectrum individuals, with some, but less consistent, differentiation of autism from PDDNOS. A priori operationalization of DSM-IV/ICD-10 criteria, factor analyses, and ROC curves were used to generate diagnostic algorithms with thresholds set for autism and broader autism spectrum/PDD. Algorithm sensitivities and specificities for autism and PDDNOS relative to nonspectrum disorders were excellent, with moderate differentiation of autism from PDDNOS.read more
Citations
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Journal ArticleDOI
Psychiatric disorders in children with autism spectrum disorders: Prevalence, comorbidity, and associated factors in a population-derived sample
TL;DR: Psychiatric disorders are common and frequently multiple in children with autism spectrum disorders and should be routinely evaluated in the clinical assessment of this group.
DatasetDOI
Autism Diagnostic Observation Schedule
Catherine Lord,Michael Rutter,Susan Goode,Jacquelyn Heemsbergen,Heather Jordan,Lynn Mawhood,Eric Schopler +6 more
Journal ArticleDOI
Global Prevalence of Autism and Other Pervasive Developmental Disorders
Mayada Elsabbagh,Gauri Divan,Yun Joo Koh,Young Shin Kim,Shuaib Kauchali,Shuaib Kauchali,Carlos Marcin,Cecilia Montiel-Nava,Vikram Patel,Cristiane Silvestre de Paula,Chongying Wang,M. T. Yasamy,Eric Fombonne +12 more
TL;DR: In this paper, a systematic review of epidemiological surveys of autistic disorder and pervasive developmental disorders (PDDs) worldwide was provided, where the authors considered the possible impact of geographic, cultural/ethnic/ethnic, and socioeconomic factors on prevalence estimates and on clinical presentation of PDD.
Journal ArticleDOI
Prevalence of disorders of the autism spectrum in a population cohort of children in South Thames: the Special Needs and Autism Project (SNAP).
Gillian Baird,Emily Simonoff,Andrew Pickles,Susie Chandler,Tom Loucas,David Meldrum,Tony Charman +6 more
TL;DR: Prevalence of autism and related ASDs is substantially greater than previously recognised and services in health, education, and social care will need to recognise the needs of children with some form of ASD, who constitute 1% of the child population.
Journal ArticleDOI
The autism brain imaging data exchange: towards a large-scale evaluation of the intrinsic brain architecture in autism
A Di Martino,C-G Yan,Qingyang Li,E Denio,Francisco X. Castellanos,Francisco X. Castellanos,Kaat Alaerts,Kaat Alaerts,Jeffrey S. Anderson,Michal Assaf,Susan Y. Bookheimer,Mirella Dapretto,Ben Deen,Ben Deen,Sonja Delmonte,Ilan Dinstein,Ilan Dinstein,Birgit Ertl-Wagner,Damien A. Fair,Louise Gallagher,Daniel P. Kennedy,Daniel P. Kennedy,Christopher L. Keown,Christian Keysers,Christian Keysers,Janet E. Lainhart,Catherine Lord,Beatriz Luna,Vinod Menon,Nancy J. Minshew,Christopher S. Monk,Sophia Mueller,R-A Müller,Mary Beth Nebel,Joel T. Nigg,Kirsten O'Hearn,Kevin A. Pelphrey,Scott Peltier,Jeffrey D. Rudie,Stefan Sunaert,Mark Thioux,Mark Thioux,J M Tyszka,Lucina Q. Uddin,Judith Verhoeven,Nicole Wenderoth,Jillian Lee Wiggins,Stewart H. Mostofsky,Stewart H. Mostofsky,Michael P. Milham,Michael P. Milham +50 more
TL;DR: W Whole-brain analyses reconciled seemingly disparate themes of both hypo- and hyperconnectivity in the ASD literature; both were detected, although hypoconnectivity dominated, particularly for corticocortical and interhemispheric functional connectivity.
References
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