Journal ArticleDOI
Solid State Fermentation Optimization of Pleurotus Ostreatus for Lovastatin Production
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In this paper, the Plackett-Burman (PB) design and response surface methodology (RSM) was used to optimize the solid state fermentation of lovastatin (HMG-CoA reductase inhibitor) for edible and medicinal mushroom Pleurotus ostreatus.Abstract:
The present study was aimed at optimization of the solid state fermentation of lovastatin (HMG-CoA reductase inhibitor) using the Plackett – Burman (PB) design and response surface methodology (RSM) for edible and medicinal mushroom Pleurotus ostreatus so as to improve Pleurotus-fermented products (like red yeast rice) with health promoting properties. According to the results of PB design, the barley, yeast extract, and particle size of the solid substrate were found to have significant effect on lovastatin production. The concentrations of barley and yeast extract and the particle size of the solid substrate were further optimized by RSM. As a result, high lovastatin production (34.97 mg/g) was achieved at the optimized conditions of barley (8 g), yeast extract (1% w/w), and particle size of the solid substrate (0.5 - 1 mm) at 28°C for 6 days.read more
Citations
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Recent developments on solid-state fermentation for production of microbial secondary metabolites: Challenges and solutions.
Vinod Kumar,Vivek Ahluwalia,Saurabh Saran,Jitendra Kumar,Anil Kumar Patel,Reeta Rani Singhania +5 more
TL;DR: In this article, the authors have identified specific SSF practices that have a significant impact on microbial secondary metabolites (SMs) production and their ease of operation and cost-effective production strategies.
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Monacolin K,A New Hypocholesterolemic Agent Produced by A Monascus Species
Akira Endo,Yue Yang +1 more
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Selected edible medicinal mushrooms from Pleurotus genus as an answer for human civilization diseases
Agata Krakowska,Piotr Zięba,Anna Wlodarczyk,Katarzyna Kała,Katarzyna Sułkowska-Ziaja,Emilia Bernaś,Agnieszka Sękara,Beata Ostachowicz,Bożena Muszyńska +8 more
TL;DR: The study revealed that the composition of biologically active substances varied between the mycelia obtained from in vitro cultures and the fruiting bodies obtained by cultivation, which were characterized by a high content of phenolic and indole compounds.
Journal ArticleDOI
Use of the Versatility of Fungal Metabolism to Meet Modern Demands for Healthy Aging, Functional Foods, and Sustainability.
Jacqueline A. Takahashi,Bianca Vianna Rodrigues Barbosa,Bruna de Almeida Martins,Christiano Pedro Guirlanda,Marília Aparecida Fidelis e Moura +4 more
TL;DR: The nutritional, pharmacological, and economic importance of fungi and their metabolites resulting from applications in the aforementioned areas are summarized, examples of modern techniques for optimizing the production of fungiand their metabolites, and methodologies for the identification and analysis of these compounds are summarized.
Journal ArticleDOI
Green Biotechnology of Oyster Mushroom (Pleurotus ostreatus L.): A Sustainable Strategy for Myco-Remediation and Bio-Fermentation
Hassan El-Ramady,Neama Abdalla,Z. F. Fawzy,Khandsuren Badgar,Xhensila Llanaj,Gréta Törős,Péter Hajdu,Yahya Z. Eid,József Prokisch +8 more
TL;DR: In this article , the authors focus on the biotechnological applications of the oyster mushroom (Pleurotus ostreatus L.) concerning the myco-remediation of pollutants and the bio-fermentation of agro-industrial wastes as a sustainable approach to environmental protection.
References
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The design of optimum multifactorial experiments
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Mevinolin: a highly potent competitive inhibitor of hydroxymethylglutaryl-coenzyme A reductase and a cholesterol-lowering agent.
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Cereal-based fermented foods and beverages
TL;DR: This review focuses first on some of the indigenous fermented foods and beverages produced world-wide that have not received the scientific attention they deserve in the last decades.
Journal ArticleDOI
Monacolin k, a new hypocholesterolemic agent produced by a monascus species
Journal ArticleDOI
A historical perspective on the discovery of statins
TL;DR: Building on that knowledge, scientists and the pharmaceutical industry have successfully developed a remarkably effective class of drugs—the statins—that lower cholesterol levels in blood and reduce the frequency of heart attacks.