Journal ArticleDOI
Solute‐Solute Interactions in Aqueous Solutions
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In this article, the authors interpreted solvent-solute interactions in aqueous solutions of nonelectrolytes using both lattice and distribution function theories of the dissolved state.Abstract:
Solute‐solute interactions in aqueous solutions of nonelectrolytes are interpreted using both lattice and distribution function theories of the dissolved state. Experimental activity data of high precision can be obtained from the literature for aqueous solutions of many nonelectrolytes. If the logarithm of the solvent activity coefficient (γ1) is expressed as a power series in the mole fraction of the solute (x2), lnγ1 = Bx22 + Cx23 + ···, then the coefficients B and C can be determined analytically from the experimental measurements. Values of B were obtained for 52 aqueous mixtures; values of C were obtained for 39 of these mixtures. The solutes considered include aliphatic alcohols, amines, amides, ketones, fatty acids, amino acids, and sugars. In some cases, experimental data were available from which the temperature dependence of the quantities B and C could also be determined. The effect of solute size on the coefficients B and C was investigated using the lattice theories of Flory, Huggins, and Gu...read more
Citations
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Journal ArticleDOI
Isoperibolic Titration Calorimetry as a Tool for the Prediction of Thermodynamic Properties of Cyclodextrins
TL;DR: In this article, the interaction of guest molecules ranging from pentan-1-ol to octan- 1-ol with α-cyclodextrin (α-CD) in water of has been studied calorimetrically at 283.15, 288.15 and 308.15 K with an isoperibolic titration calorimeter designed in their laboratory.
Journal ArticleDOI
A novel amorphous solid dispersion based on drug-polymer complexation.
TL;DR: Improved RAF release in the complexation-based ASD is due to high energy state of RAF owing to the amorphous form, high pH in the microenvironment due to the ionized state ofRAF and residual sodium hydroxide, increased apparent solubility of RAF results from RAF-PVP complexation in dissolution media and biological media, and improved wettability.
Journal ArticleDOI
Thermodynamics of the ethylene glycol pair interaction with some amino acids and benzene
Andrey V. Kustov,Andrey V. Kustov,Olga A. Antonova,Olga A. Antonova,Nataliya L. Smirnova,Nataliya L. Smirnova +5 more
TL;DR: In this paper, the thermodynamics of interaction of benzene and some amino acids with ethylene glycol (Eg) which is a stabilizing agent for proteins in water using calorimetric and solubility data.
DissertationDOI
Charge effect on protein partitioning in aqueous two-phase systems
TL;DR: In this article, the authors propose a novel approach to solve the problem of homonymity in homonymization, i.e., homonymonymity-of-homonymity.
Journal ArticleDOI
Physico-chemical properties of aqueous drug solutions: From the basic thermodynamics to the advanced experimental and simulation results
TL;DR: This paper is intended to provide a collective view on the latest literature results, still the presentation aims at a tutorial explanation of the potentials of the three methodologies in the field of aqueous solutions of pharmaceutical molecules.
References
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Book
Molecular theory of gases and liquids
TL;DR: Molecular theory of gases and liquids as mentioned in this paper, molecular theory of gas and liquids, Molecular theory of liquid and gas, molecular theories of gases, and liquid theory of liquids, مرکز
Book ChapterDOI
Some factors in the interpretation of protein denaturation.
TL;DR: The chapter reviews that the denaturation is a process in which the spatial arrangement of the polypeptide chains within the molecule is changed from that typical of the native protein to a more disordered arrangement.
Journal ArticleDOI
Thermodynamics of High Polymer Solutions
TL;DR: In this paper, a statistical treatment of high polymer solutions has been carried out on the basis of an idealized model, originally proposed by Meyer, which is analogous to the one ordinarily assumed in the derivation of the ''ideal'' solution laws for molecules of equal size.
Journal ArticleDOI
Free Volume and Entropy in Condensed Systems III. Entropy in Binary Liquid Mixtures; Partial Molal Entropy in Dilute Solutions; Structure and Thermodynamics in Aqueous Electrolytes
Henry S. Frank,Marjorie W. Evans +1 more
TL;DR: The first and second papers in this series, which make it possible to interpret entropy data in terms of a physical picture, are applied to binary solutions, and equations are derived relating energy and volume changes when a solution is formed to the entropy change for the process as discussed by the authors.
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