Journal ArticleDOI
Solvent‐Free Synthesis of 2‐(Phenylamino)‐4‐(trifluoromethyl)‐1,6‐dihydropyrimidine Derivatives Catalyzed by Sulfamic Acid.
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TLDR
In this article, a series of 2-(phenylamino)-4-(trifluoromethyl)-1,6-dihydropyrimidine derivatives were synthesized efficienly via the reaction of aryl aldehyde, ethyl 4,4,4-trifi-oro-3-oxobutanoate and 1-phenylguanidine carbonate catalyzed by sulfamic acid under solvent-free conditions.Abstract:
A series of 2-(phenylamino)-4-(trifluoromethyl)-1,6-dihydropyrimidine derivatives were synthesized efficienly via the reaction of aryl aldehyde, ethyl 4,4,4-trifluoro-3-oxobutanoate and 1-phenylguanidine carbonate catalyzed by sulfamic acid under solvent-free conditions. This protocol has the advantages of mild condition, high yields and environmentally benign procedure.read more
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Journal ArticleDOI
Solvent‐Free Synthesis of 2‐(Phenylamino)‐4‐(trifluoromethyl)‐1,6‐dihydropyrimidine Derivatives Catalyzed by Sulfamic Acid
TL;DR: In this article, a series of 2-(phenylamino)-4-(trifluoromethyl)-1,6-dihydropyrimidine derivatives were synthesized efficienly via the reaction of aryl aldehyde, ethyl 4,4,4-trifi-oro-3-oxobutanoate and 1-phenylguanidine carbonate catalyzed by sulfamic acid under solvent-free conditions.