Journal ArticleDOI
Solvent‐Free Synthesis of 2‐(Phenylamino)‐4‐(trifluoromethyl)‐1,6‐dihydropyrimidine Derivatives Catalyzed by Sulfamic Acid
TLDR
In this article, a series of 2-(phenylamino)-4-(trifluoromethyl)-1,6-dihydropyrimidine derivatives were synthesized efficienly via the reaction of aryl aldehyde, ethyl 4,4,4-trifi-oro-3-oxobutanoate and 1-phenylguanidine carbonate catalyzed by sulfamic acid under solvent-free conditions.About:
This article is published in Journal of Heterocyclic Chemistry.The article was published on 2012-09-01. It has received 2 citations till now. The article focuses on the topics: Sulfamic acid & Trifluoromethyl.read more
Citations
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Multicomponent reactions of ethyl trifluoroacetoacetate with carbonyl and nucleophilic reagents as a promising tool for organic synthesis
Journal ArticleDOI
Solvent‐Free Synthesis of 2‐(Phenylamino)‐4‐(trifluoromethyl)‐1,6‐dihydropyrimidine Derivatives Catalyzed by Sulfamic Acid.
TL;DR: In this article, a series of 2-(phenylamino)-4-(trifluoromethyl)-1,6-dihydropyrimidine derivatives were synthesized efficienly via the reaction of aryl aldehyde, ethyl 4,4,4-trifi-oro-3-oxobutanoate and 1-phenylguanidine carbonate catalyzed by sulfamic acid under solvent-free conditions.
References
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Green solvents for sustainable organic synthesis: state of the art
TL;DR: A review of the state of the art in the use of alternative reaction media for green, sustainable organic synthesis is presented in this article, where a novel and effective method for the immobilisation of enzymes as cross-linked enzyme aggregates (CLEAs) is discussed and a combi CLEA, containing two enzymes, for the one-pot conversion of benzaldehyde to S-mandelic acid is reported.
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Recent advances in the Biginelli dihydropyrimidine synthesis. New tricks from an old dog.
TL;DR: This Account highlights recent developments in the Biginelli reaction in areas such as solid-phase synthesis, combinatorial chemistry, and natural product synthesis.
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Fluorine in medicinal chemistry: Recent therapeutic applications of fluorinated small molecules
TL;DR: Fluorinated drugs for treatment of diseases of the central nervous system, various cardiovascular diseases and obesity, antibacterial agents, and antifungal therapy are reviewed.
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TL;DR: 1. Six-Membered Heterocycles with One Heteroatom 4155 7.6.1.
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Recent advances (1995–2005) in fluorinated pharmaceuticals based on natural products ☆
TL;DR: In this article, the authors present a report devoted to the recent advances, in these last 10 years, in fluorinated analogues of natural products developed as pharmaceuticals, marketed, registered or in clinical development.