Open AccessJournal Article
Stereospecific inhibition of alkaline phosphatase by L-tetramisole prevents in vitro cartilage calcification.
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TLDR
The data show that there is a close association between ALP activity and in vitro calcification of rachitic rat cartilage, and suggest that some ATPase activity of rACHitic rat Cartilage may be distinct from ALP activity.About:
This article is published in Laboratory Investigation.The article was published on 1980-01-26 and is currently open access. It has received 113 citations till now. The article focuses on the topics: Cartilage metabolism & Calcification.read more
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Tissue-nonspecific alkaline phosphatase and plasma cell membrane glycoprotein-1 are central antagonistic regulators of bone mineralization
Lovisa Hessle,Kristen Johnson,H. Clarke Anderson,Sonoko Narisawa,Adnan Sali,James W. Goding,Robert Terkeltaub,José Luis Millán +7 more
TL;DR: The results suggest that inhibiting PC-1 function may be a viable therapeutic strategy for hypophosphatasia, and interfere with TNAP activity may correct pathological hyperossification because of PPi insufficiency.
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Hypophosphatasia and the role of alkaline phosphatase in skeletal mineralization.
TL;DR: How ALP acts was clarified by the discoveries that several phosphocompound substrates for tissue-nonspecific ALP (TNSALP) accumulate endogenously in this inborn error of metabolism.
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Alkaline Phosphatases : Structure, substrate specificity and functional relatedness to other members of a large superfamily of enzymes
TL;DR: This mini-review focuses exclusively on structural and functional features of mammalian alkaline phosphatases as identified by crystallography and probed by site-directed mutagenesis and kinetic analysis and their structural andfunctional relatedness to a large superfamily of enzymes that includes nucleotide pyrophosphatase/phosphodiesterase.
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Initiation and progression of mineralization of bone nodules formed in vitro: the role of alkaline phosphatase and organic phosphate
TL;DR: In this article, the authors show that the initiation and progression of bone nodule mineralization are separate phenomena and that organic phosphate and alkaline phosphatase play a crucial role in the initiation of mineralization.
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Impaired Calcification Around Matrix Vesicles of Growth Plate and Bone in Alkaline Phosphatase-Deficient Mice
H. Clarke Anderson,Joseph B. Sipe,Lovisa Hessle,Rama Dhamyamraju,Elisa Atti,Nancy P. Camacho,José Luis Millán +6 more
TL;DR: The data suggest that hypomineralization in TNAP-deficient mice results primarily from an inability of initial mineral crystals within MVs to self-nucleate and to proliferate beyond the protective confines of the MV membrane, which may be caused by an excess of the mineral inhibitor pyrophosphate in the extracellular fluid around MVs.