Journal ArticleDOI
Steric and Electronic Effects, Enantiospecificity, and Reactive Orientation in DNA Binding/Cleaving by Substituted Derivatives of [SalenMn(III)](+).
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TLDR
Twenty-six derivatives of [SalenMn(III)](+) bearing halogen, nitro, amino, ether, alkyl, or aryl substituents on the aromatic rings and/or at the imine positions or containing 1,3-propylene', 1,2-phenylene-, 1, 2-cyclohexane-, or 1,1-diphenylethylenediamine as the bridging moiety have been synthesized.Abstract:
Twenty-six derivatives of [SalenMnIII]+ (1) bearing halogen, nitro, amino, ether, alkyl, or aryl substituents on the aromatic rings and/or at the imine positions or containing 1,3-propylene-, 1,2-p...read more
Citations
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Journal ArticleDOI
Oxidative Nucleobase Modifications Leading to Strand Scission
Journal ArticleDOI
The Mechanistic Basis for Electronic Effects on Enantioselectivity in the (salen)Mn(III)-Catalyzed Epoxidation Reaction
Michael Palucki,Nathaniel S. Finney,Paul J. Pospisil,Mehmet L. Guler,Toyohisa Ishida,Eric N. Jacobsen +5 more
TL;DR: In this article, it was shown that enantioselectivity in the (salen)mn-catalyzed asymmetric epoxidation reaction correlates directly with the electronic properties of the ligand substituents.
Journal ArticleDOI
DNA binding and DNA cleavage studies of a water soluble cobalt(II) complex containing dinitrogen Schiff base ligand: The effect of metal on the mode of binding
TL;DR: Multi-spectroscopic experiments reveal that the binding modes of Co( II) complex in comparison with SF are different; SF may be intercalating between DNA base pairs while its Co(II) complex most likely interact with DNA in an electrostatic binding mode.
Journal ArticleDOI
Design of artificial metallonucleases with oxidative mechanism
TL;DR: This review will highlight the most recent progress in the area of artificial metallonucleases employing an oxidative mechanism, focusing on the development of methodologies for cleavage detection, understanding of the factors governing the Cleavage efficacy and selectivity, and design strategies for the achievement of high cleavage efficacy.
Journal ArticleDOI
Copper(II) complexes of 1,10-phenanthroline-derived ligands: studies on DNA binding properties and nuclease activity.
Tomoya Hirohama,Yuko Kuranuki,Eriko Ebina,Takashi Sugizaki,Hidekazu Arii,Makoto Chikira,Pitchumony Tamil Selvi,Mallayan Palaniandavar +7 more
TL;DR: Interestingly, [Cu(L5)]2+ shows the highest DNA cleavage activity among all the present copper(II) complexes suggesting that the bulky N-tert-butyl group plays an important role in modifying the coordination environment around the copper( II) center, the Cu(II)/Cu(I) redox potential and hence the formation of activated oxidant responsible for the cleavage.
References
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Journal ArticleDOI
Design of sequence-specific DNA-binding molecules.
TL;DR: This work has produced bis(distamycin)fumaramide, a synthetic, crescent-shaped oligopeptide that binds nine contiguous adenine-thymine base pairs in the minor groove of double-helical DNA.
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Epoxidation of olefins with cationic (salen)manganese(III) complexes. The modulation of catalytic activity by substituents.
TL;DR: Augmentation d'activite avec des substituants attracteurs d'electrons (dichloro ou dinitro)
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The molecular origin of DNA-drug specificity in netropsin and distamycin
TL;DR: The netropsin molecule has an intrinsic twist that favors insertion into the minor groove of B-DNA, and it is given a small additional twist upon binding, which could lead to a class of synthetic "lexitropsins," capable of reading any desired short sequence of DNA base pairs.
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Cleavage of DNA with methidiumpropyl-EDTA-iron(II): reaction conditions and product analyses
TL;DR: The synthesis of methidiumpropyl-EDTA (MPE) is described and the released products are consistent with the oxidative degradation of the deoxyribose ring of the DNA backbone, most likely by hydroxy radical.