Stigmasterol: a phytosterol with potential anti-osteoarthritic properties
Odile Gabay,Christelle Sanchez,Christelle Sanchez,Colette Salvat,Françoise Chevy,Michelyne Breton,Geoffroy Nourissat,Claude Wolf,Claire Jacques,Francis Berenbaum +9 more
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TLDR
This study shows that stigmasterol inhibits several pro-inflammatory and matrix degradation mediators typically involved in OA-induced cartilage degradation, at least in part through the inhibition of the NF-kappaB pathway.About:
This article is published in Osteoarthritis and Cartilage.The article was published on 2010-01-01 and is currently open access. It has received 308 citations till now. The article focuses on the topics: Stigmasterol & Chondrocyte.read more
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Inflammation in osteoarthritis
Mary B. Goldring,Miguel Otero +1 more
TL;DR: This review focuses on the novel stress-induced and proinflammatory mechanisms underlying the pathogenesis of osteoarthritis, with particular attention to the role of synovitis and the contributions of other joint tissues to cellular events that lead to the onset and progression of the disease and irreversible cartilage damage.
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Chondrogenesis, chondrocyte differentiation, and articular cartilage metabolism in health and osteoarthritis.
TL;DR: Understanding how the chondrocytes in adult human cartilage undergo phenotypic modulation and promote matrix destruction and abnormal repair in OA may to lead to identification of critical targets for therapy to block cartilage damage and promote effective cartilage repair.
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Homeostatic mechanisms in articular cartilage and role of inflammation in osteoarthritis
TL;DR: This review focuses on mechanisms responsible for the maintenance of cartilage homeostasis and highlights the role of inflammatory processes in OA progression.
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The Story of Beta-sitosterol-A Review
TL;DR: Phytosterols are a subgroup of the steroids, as an important class of bioorganic molecules, widespread in plants, animals, marines as well as fungi and have similarity to cholesterol in structure.
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Current and new insights on phytosterol oxides in plant sterol-enriched food.
TL;DR: The final objective of this overview is to evince the different aspects of plant sterols-enriched food that require further research, for a better understanding of the influence of Plant sterols and their oxides on consumers' health.
References
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A rapid method of total lipid extraction and purification.
E. G. Bligh,W. J. Dyer +1 more
TL;DR: The lipid decomposition studies in frozen fish have led to the development of a simple and rapid method for the extraction and purification of lipids from biological materials that has been applied to fish muscle and may easily be adapted to use with other tissues.
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Nuclear factor-κB: The enemy within
TL;DR: The NF-kappaB proteins themselves and proteins regulated by it have been linked to cellular transformation, proliferation, apoptosis suppression, invasion, angiogenesis, and metastasis as mentioned in this paper.
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Deletion of active ADAMTS5 prevents cartilage degradation in a murine model of osteoarthritis
S.S. Glasson,Roger Askew,Barbara Sheppard,Brenda A. Carito,Tracey Blanchet,Hak-Ling Ma,Carl R. Flannery,Peluso Diane,Kim Kanki,Zhiyong Yang,Manas K. Majumdar,Elisabeth A. Morris +11 more
TL;DR: It is demonstrated that ADAMTS5 is the primary ‘aggrecanase’ responsible for aggrecan degradation in a murine model of osteoarthritis, and rational strategies for therapeutic intervention in osteOarthritis are suggested.
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Aging and osteoarthritis: the role of chondrocyte senescence and aging changes in the cartilage matrix
TL;DR: The effects of aging on chondrocytes and their matrix result in a tissue that is less able to maintain homeostasis when stressed, resulting in breakdown and loss of the articular cartilage, a hallmark of OA.