Journal ArticleDOI
Structure-activity and dose-response relationships in the neural and behavioral teratogenesis of retinoids
TLDR
In this paper, the effects of three retinoid compounds (retinol, all-trans retinoic acid (tretinoin), and 13-cis retinoisotretin) with respect to effects on central nervous system malformations and postnatal death, growth reduction, and behavioral dysfunction were investigated.About:
This article is published in Neurotoxicology and Teratology.The article was published on 1993-05-01. It has received 61 citations till now. The article focuses on the topics: Tretinoin & Retinoic acid.read more
Citations
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Journal ArticleDOI
Chiral Toxicology: It's the Same Thing…Only Different
TL;DR: Chiral substances possess a unique architecture such that, despite sharing identical molecular formulas, atom-to-atom linkages, and bonding distances, they cannot be superimposed as discussed by the authors.
REVIEW Chiral Toxicology: It's the Same Thing ... Only Different
TL;DR: Environmental toxicology provides several examples in which compound bioaccumulation, persistence, and toxicity show chiral dependence, and chiral analysis has been applied to illicit drug preparations and biological specimens, with the potential to assist in determination of cause of death and aid in the correct interpretation of substance abuse and "doping" screens.
Journal ArticleDOI
Human pluripotent stem cell-derived neural constructs for predicting neural toxicity
Michael P. Schwartz,Zhonggang Hou,Nicholas E. Propson,Jue Zhang,Collin Engstrom,Vítor Santos Costa,Peng Jiang,Bao Kim Nguyen,Jennifer M. Bolin,William T. Daly,Yu Wang,Ron Stewart,C. David Page,William L. Murphy,James A. Thomson,James A. Thomson,James A. Thomson +16 more
TL;DR: Stem cell biology, tissue engineering, bioinformatics, and machine learning were combined to implement an in vitro human cellular model for developmental neurotoxicity screening and demonstrated the value of human cell-based assays for predictive toxicology and should be useful for both drug and chemical safety assessment.
Journal ArticleDOI
Complex regulation of cyp26a1 creates a robust retinoic acid gradient in the zebrafish embryo.
TL;DR: Using cell transplantation and implantation of RA-coated beads into RA-deficient zebrafish embryos, it is demonstrated that RA can directly convey graded positional information over long distances, and expression of Cyp26a1, the major RA-degrading enzyme during gastrulation, is under complex feedback and feedforward control.
Journal ArticleDOI
13-cis-retinoic acid suppresses hippocampal cell division and hippocampal-dependent learning in mice
James E. Crandall,Yasuo Sakai,Jinhua Zhang,Omanand Koul,Yann S. Mineur,Wim E. Crusio,Peter McCaffery +6 more
TL;DR: It is demonstrated that a clinical dose of 13-cis-RA in mice significantly reduces cell proliferation in the hippocampus and the subventricular zone, suppresses hippocampal neurogenesis, and severely disrupts capacity to learn a spatial radial maze task.
References
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Journal ArticleDOI
Retinoic Acid Embryopathy
TL;DR: It is possible that a major mechanism of isotretinoin teratogenesis is a deleterious effect on cephalic neural-crest cell activity that results in the observed craniofacial, cardiac, and thymic malformations.
Book
Handbook of infant development
TL;DR: The Behavioral Assessment of Neonate: An Overview Neonatal Behavioral Assessment Scale Applying Observational Methods: A Systematic View Analysis of Sequential Social Intervention Data: Social Intervention data: Some Issues, Recent Developments and Causal Inference Model Index as mentioned in this paper.
Journal ArticleDOI
Retinoic acid causes an anteroposterior transformation in the developing central nervous system.
Antony J. Durston,J. P. M. Timmermans,W. J. Hage,H.F.J. Hendriks,N. J. de Vries,M. Heideveld,P. D. Nieuwkoop +6 more
TL;DR: It is found that RA acts on the developing CNS, transforming anterior neural tissue to a posterior neural specification, raising the possibility that RA mediates an inductive interaction regulating anteroposterior differentiation within the CNS.
Book ChapterDOI
Cellular Biology and Biochemistry of the Retinoids
TL;DR: In this paper, the cellular biology and biochemistry of the retinoids are discussed and the effects of retinoid on cell differentiation in many different types of epithelia.
Journal ArticleDOI
Morphogenesis of malformations in hamsters caused by retinoic acid: relation to dose and stage at treatment.
TL;DR: Female golden hamsters were each given a single administration of retinoic acid sodium salt at one of 20 stages in pregnancy, and forty types of malformation whose incidence was 10% or more at the fetal LD50 dose at some time in pregnancy were studied.