N
Nicholas E. Propson
Researcher at Baylor College of Medicine
Publications - 26
Citations - 4099
Nicholas E. Propson is an academic researcher from Baylor College of Medicine. The author has contributed to research in topics: Microglia & Neuroinflammation. The author has an hindex of 13, co-authored 21 publications receiving 3085 citations. Previous affiliations of Nicholas E. Propson include University of California, Santa Barbara & Wisconsin Alumni Research Foundation.
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Journal ArticleDOI
Chemically defined conditions for human iPSC derivation and culture
Guokai Chen,Daniel R. Gulbranson,Daniel R. Gulbranson,Zhonggang Hou,Zhonggang Hou,Jennifer M. Bolin,Victor Ruotti,Mitchell D. Probasco,Kimberly Smuga-Otto,Sara E. Howden,Sara E. Howden,Nicole R. Diol,Nicole R. Diol,Nicholas E. Propson,Nicholas E. Propson,Ryan J. Wagner,Ryan J. Wagner,Garrett O. Lee,Garrett O. Lee,Jessica Antosiewicz-Bourget,Joyce M.C. Teng,James A. Thomson +21 more
TL;DR: A cell culture system in which all protein reagents for liquid media, attachment surfaces and splitting are chemically defined is formed, and improved derivation efficiencies of vector-free human iPSCs with an episomal approach are demonstrated.
Journal ArticleDOI
Epigenomic Analysis of Multilineage Differentiation of Human Embryonic Stem Cells
Wei Xie,Matthew D. Schultz,Ryan Lister,Zhonggang Hou,Nisha Rajagopal,Pradipta R. Ray,John W. Whitaker,Shulan Tian,R. David Hawkins,Danny Leung,Hongbo Yang,Tao Wang,Ah Young Lee,Scott Swanson,Jiuchun Zhang,Jiuchun Zhang,Yun Zhu,Audrey Kim,Joseph R. Nery,Mark A. Urich,Samantha Kuan,Chia-An Yen,Sarit Klugman,Pengzhi Yu,Kran Suknuntha,Nicholas E. Propson,Huaming Chen,Lee Edsall,Ulrich Wagner,Yan Li,Zhen Ye,Ashwinikumar Kulkarni,Zhenyu Xuan,Wen Yu Chung,Neil C. Chi,Jessica Antosiewicz-Bourget,Igor I. Slukvin,Ron Stewart,Michael Q. Zhang,Michael Q. Zhang,Wei Wang,James A. Thomson,James A. Thomson,James A. Thomson,Joseph R. Ecker,Bing Ren,Bing Ren +46 more
TL;DR: It is found that promoters that are active in early developmental stages tend to be CG rich and mainly engage H3K27me3 upon silencing in nonexpressing lineages, while promoters for genes expressed preferentially at later stages are often CG poor and primarily employ DNA methylation upon repression.
Journal ArticleDOI
Efficient genome engineering in human pluripotent stem cells using Cas9 from Neisseria meningitidis
Zhonggang Hou,Yan Zhang,Nicholas E. Propson,Sara E. Howden,Li-Fang Chu,Erik J. Sontheimer,James A. Thomson,James A. Thomson,James A. Thomson +8 more
TL;DR: Efficient targeting of an endogenous gene in three hPSC lines using HDR is demonstrated using a distinct CRISPR-Cas system identified in Neisseria meningitidis, which is distinct from the commonly used Streptococcus pyogenes system.
Journal ArticleDOI
Human pluripotent stem cell-derived neural constructs for predicting neural toxicity
Michael P. Schwartz,Zhonggang Hou,Nicholas E. Propson,Jue Zhang,Collin Engstrom,Vítor Santos Costa,Peng Jiang,Bao Kim Nguyen,Jennifer M. Bolin,William T. Daly,Yu Wang,Ron Stewart,C. David Page,William L. Murphy,James A. Thomson,James A. Thomson,James A. Thomson +16 more
TL;DR: Stem cell biology, tissue engineering, bioinformatics, and machine learning were combined to implement an in vitro human cellular model for developmental neurotoxicity screening and demonstrated the value of human cell-based assays for predictive toxicology and should be useful for both drug and chemical safety assessment.
Journal ArticleDOI
Complement C3aR Inactivation Attenuates Tau Pathology and Reverses an Immune Network Deregulated in Tauopathy Models and Alzheimer’s Disease
Alexandra Litvinchuk,Ying Wooi Wan,Dan B. Swartzlander,Fading Chen,Allysa L. Cole,Nicholas E. Propson,Qian Wang,Bin Zhang,Zhandong Liu,Hui Zheng +9 more
TL;DR: It is shown that the expression of C3 and C3a receptor (C3aR1) are positively correlated with cognitive decline and Braak staging in human AD brains and a crucial role for activation of the C3-C3 aR network in mediating neuroinflammation and tau pathology is demonstrated.