Journal ArticleDOI
Structure and mechanism in the enzymic activity of carboxypeptidase A and relations to chemical sequence
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This article is published in Accounts of Chemical Research.The article was published on 1970-03-01. It has received 126 citations till now. The article focuses on the topics: Carboxypeptidase A & Carboxypeptidase.read more
Citations
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Journal ArticleDOI
Model studies of carboxypeptidase A
TL;DR: In this article, the catalytic roles of the Glu-270 carboxylate group and the metal ion are investigated in a bifunctional CPA system, where both the carboxyclic and anionic forms of Glu 270 are present.
Journal ArticleDOI
Inhibition of carboxypeptidase a by N-(4-t-Butylbenzoyl)-2-hydroxy-1-naphthaldehyde hydrazone
TL;DR: Molecular modeling studies suggest that N-(4-t-Butylbenzoyl)-2-hydroxy-1-naphthaldehyde hydrazone may inhibit CPA by binding to the S1 and S2 subsites of free CPA as well as to the CPA-phenylalanine binary enzyme-product complex.
Journal ArticleDOI
Equilibrium studies on metal-peptide systems—I: Polarographic determination of association constants of cadmium(II), zinc(II) and lead(II) complexes of glycylgycine
Kamalaksha Nag,Pradyot Banerjee +1 more
TL;DR: In this article, the equilibria involved in the association of Cd2+, Zn2+ and Pb2+ with glycylglycine have been investigated polarographically (at 25°C).
Journal ArticleDOI
On the Mechanism of Accelaration of Carboxypeptidase A Activity
Isreal Schechter,Etty Zazepizki +1 more
TL;DR: A number of peptides derivatives were found to increase the peptides activity of caboxypeptidase A towards benzyloxycarbonyl-depeptides, and studies indicate that an EA complex is formed, and that EA reacts with S to form an active ternary complex, EAS.
References
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Journal ArticleDOI
Structure of hen egg-white lysozyme. A three-dimensional Fourier synthesis at 2 Angstrom resolution.
C. C. F. Blake,D. F. Koenig,D. F. Koenig,G. A. Mair,A. C. T. North,D. C. Phillips,V. R. Sarma +6 more
TL;DR: Structure of Hen Egg-White Lysozyme: A Three-dimensional Fourier Synthesis at 2 A Resolution as mentioned in this paper, 3D Fourier synthesis at 2 a resolution.
Journal ArticleDOI
Structure of Myoglobin: A Three-Dimensional Fourier Synthesis at 2 Å. Resolution
J. C. Kendrew,R. E. Dickerson,B. E. Strandberg,R G Hart,D R Davies,D. C. Phillips,V. C. Shore +6 more
Journal ArticleDOI
Structure of papain.
TL;DR: A three-dimensional X-ray study at a resolution of 2.8 A has revealed that the single polypeptide chain of 211 residues is folded into two distinct parts which are divided by a cleft as mentioned in this paper.
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