Journal ArticleDOI
Structure and mechanism in the enzymic activity of carboxypeptidase A and relations to chemical sequence
About:
This article is published in Accounts of Chemical Research.The article was published on 1970-03-01. It has received 126 citations till now. The article focuses on the topics: Carboxypeptidase A & Carboxypeptidase.read more
Citations
More filters
Journal ArticleDOI
Dynamics of folded proteins
TL;DR: The dynamics of a folded globular protein have been studied by solving the equations of motion for the atoms with an empirical potential energy function and suggest that the protein interior is fluid-like in that the local atom motions have a diffusional character.
Journal ArticleDOI
Synthetic analogues relevant to the structure and function of zinc enzymes.
Journal ArticleDOI
Analog approaches to the structure of the transition state in enzyme reactions
Journal ArticleDOI
The internal dynamics of globular proteins.
Martin Karplus,J. A. McCammon +1 more
TL;DR: The Internal Dynamics of Globular Protein (IDGP) as mentioned in this paper is a well-known model for the internal dynamics of protein structures and its dynamics in the context of protein synthesis.
Book ChapterDOI
Carboxypeptidase A: a protein and an enzyme.
TL;DR: This chapter discusses the relationship of the three-dimensional structures of bovine carboxypeptidase A, and of its complexes with substrates and inhibitors, to the functional behavior of this enzyme.
References
More filters
Journal ArticleDOI
The n-terminal sequence of bovine carboxypeptidase a and its relation of zymogen activation.
Journal ArticleDOI
Procedures for the isolation of crystalline bovine pancreatic carboxypeptidase a. i. isolation from acetone powders of pancreas glands.
Journal ArticleDOI
The physical properties of metal-free carboxypeptidase.
John A. Rupley,Hans Neurath +1 more
Journal ArticleDOI
Nitrogen and sulphur at the active centre of carboxypeptidase A.
Bert L. Vallee,Bert L. Vallee,Robert J. P. Williams,Robert J. P. Williams,Joseph E. Coleman,Joseph E. Coleman +5 more
TL;DR: It has been suggested that a sulphur and a nitrogen atom of carboxypeptidase, together with a metal atom, constitute the active centre of the enzyme, their interaction being required for activity.
Related Papers (5)
Metallocarboxypeptidases: stability constants and enzymatic characteristics.
Joseph E. Coleman,Bert L. Vallee +1 more