Journal ArticleDOI
Studies on chemiluminescence and protein kinase-C activity of cisplatin treated mouse peritoneal exudate cells.
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It is observed that in vitro treatment of macrophages with cisplatin, rIFN-gamma and LPS show increased activity of the protein kinase-C (PK-C), which suggests that this activation is energy dependent.Abstract:
A single i.p. injection of cisplatin (10 mg/kg body weight) into mice results in a significant increase in chemiluminescence and ATP contents of the peritoneal exudate cells (PEC) than that of PEC from untreated mice. It is also observed that in vitro treatment of macrophages with cisplatin, rIFN-gamma and LPS show increased activity of the protein kinase-C (PK-C). The activation of PK-C could result in stimulation of NADPH-oxidase resulting in increased levels of chemiluminescence. Increased contents of ATP in PEC after cisplatin treatment also suggests that this activation is energy dependent.read more
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Journal ArticleDOI
Metal-containing and related polymers for biomedical applications
TL;DR: This review summarizes the following biomedical applications of metal-containing polymers, including antimicrobial and antiviral agents, anticancer drugs, photodynamic therapy agents, radiotherapy agents and biocides, and metal- containing polymers in bioimaging.
Journal ArticleDOI
Effects of platinum and palladium ions on the production and reactivity of neutrophil-derived reactive oxygen species.
TL;DR: It is demonstrated that Pt and Pd potentiate the reactivity, as opposed to the generation of neutrophil-derived oxidants, an activity that may contribute to airway inflammation in occupationally and possibly environmentally exposed individuals.
Journal ArticleDOI
Comparison of the effects of cisplatin and a novel platinum polymer conjugate on the production of reactive oxygen species by human neutrophils in vitro
TL;DR: Taken together with their impressive and selective anti‐proliferative effects on tumor cells, the absence of pro‐oxidative interactions of Pt‐6 and Pt‐7 with human neutrophils further underscores the clinical potential of these novel anticancer agents.
Book ChapterDOI
Plant Metabolites as Immunomodulators
Sony Jayaraman,Jayadevi Variyar +1 more
TL;DR: A large number of synthetic compounds are currently used for augmenting the immune system causing variety of side effects as discussed by the authors using natural biomolecules which are benign and economical can lead to safe immunomodulation.
References
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Joseph C. Fantone,P. A. Ward +1 more
Journal ArticleDOI
Evidence for the generation of an electronic excitation state(s) in human polymorphonuclear leukocytes and its participation in bactericidal activity
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Assays of protein kinase.
TL;DR: The radioisotopic method for cAMP-dependent protein kinase can be used with tissue homogenates and purified enzyme, and the spectrophotometric assay is valuable in enzyme kinetic studies as it is continuous.
Journal ArticleDOI
Phagocytic activation of a luminol-dependent chemiluminescence in rabbit alveolar and peritoneal macrophages.
Robert C. Allen,L.D. Loose +1 more
TL;DR: The chemiluminescent response obtained was of high intensity, and could be easily monitored using the standard in-coincidence scintillation spectrophotometry equipment employed in routine isotope counting.
Journal ArticleDOI
Increased production of superoxide anion by macrophages exposed in vitro to muramyl dipeptide or lipopolysaccharide.
M J Pabst,R B Johnston +1 more
TL;DR: The data suggest that previous exposure to bacterial products could prime macrophages to respond with increased production of toxic oxygen metabolites on contact with invading microorganisms or tumor cells.
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