Journal ArticleDOI
Studies on the immunomodulatory effects of Ashwagandha.
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TLDR
Treatment with Ashwagandha was accompanied by significant increases in hemolytic antibody responses towards human erythrocytes, which prevented myelosuppression in mice treated with all three immunosuppressive drugs tested.About:
This article is published in Journal of Ethnopharmacology.The article was published on 1996-02-01. It has received 360 citations till now. The article focuses on the topics: Withania somnifera & White blood cell.read more
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Journal ArticleDOI
Immunomodulatory role of Withania somnifera root powder on experimental induced inflammation: An in vivo and in vitro study.
TL;DR: The aqueous suspension of Withania somnifera root powder showed potent inhibitory activity towards the complement system, mitogen induced lymphocyte proliferation and delayed-type hypersensitivity reaction, thus it could be a candidate for developing as an immunosuppressive drug for the inflammatory diseases.
Journal ArticleDOI
A standardized root extract of Withania somnifera and its major constituent withanolide-A elicit humoral and cell-mediated immune responses by up regulation of Th1-dominant polarization in BALB/c mice.
Fayaz Malik,Jaswant Singh,Anamika Khajuria,Krishan Avtar Suri,Naresh Kumar Satti,Surjeet Singh,Maharaj K. Kaul,Arun Kumar,Aruna Bhatia,Ghulam Nabi Qazi +9 more
TL;DR: The studies suggested that AGB supports predominantly Th1 immunity with increase in macrophage functions and might therefore, find useful applications against the intracellular pathogens and in the management of immune suppressed diseases.
Journal ArticleDOI
Immunomodulatory effects of agents of plant origin.
TL;DR: It is suggested that both the herbal extracts caused immunosuppression in AIA rats, indicating that they may provide an alternative approach to the treatment of arthritis.
Journal ArticleDOI
Withaferin A induces apoptosis by activating p38 mitogen-activated protein kinase signaling cascade in leukemic cells of lymphoid and myeloid origin through mitochondrial death cascade.
Chandan Mandal,Avijit Dutta,Avijit Dutta,Asish Mallick,Sarmila Chandra,Laxminarain Misra,Rajender S. Sangwan,Chitra Mandal +7 more
TL;DR: Findings suggest that p38MAPK in leukemic cells promotes WA-induced apoptosis, and therefore WA holds promise as a new, alternative, inexpensive chemotherapeutic agent for the treatment of patients with leukemia of both lymphoid and myeloid origin.
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Effect of some Indian herbs on macrophage functions in ochratoxin A treated mice
TL;DR: Treatment with Indian herbs significantly inhibited OTA-induced suppression of chemotactic activity and production of IL-1 and TNF-alpha by macropahges and it was found that Withania somnifera treated macrophage chemotaxis and that Asparagus racemosus induced excess production of T NF-alpha when compared with controls.
References
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Book
The pharmacological basis of therapeutics
TL;DR: In this article, 42 authors share the herculean task of reviewing the flood of recent literature on pharmacology and rational use of drugs, under single or dual authorship they contribute the 76 chapters in the 18 sections.
Book
Thin-layer chromatography : a laboratory handbook
TL;DR: Thin-Layer Chromatography edited by E. Stahl (+) is the standard laboratory reference book for applications of this analytical method in chemical, pharmaceutical and clinical analysis.
Journal ArticleDOI
A comparative pharmacological investigation of Ashwagandha and Ginseng.
TL;DR: The aqueous suspensions of roots of an Indian drug Ashwagandha and the Korean drug Ginseng were tested comparatively for 2 pharmacological activities, namely the anti-stress activity by the 'mice swimming endurance test' and anabolic activity by noting gain in body weights and levator ani muscle in rats.