Journal ArticleDOI
Substance P injected into the region of the nucleus basalis magnocellularis facilitates performance of an inhibitory avoidance task
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The influence of SP on the performance of the single trial “uphill avoidance task” was tested and the post-trial injection of 1 ng SP led to significantly longer latencies in the uphill response.Abstract:
The neuropeptide substance P (SP) was injected into the region of the nucleus basalis magnocellularis (NBM). The influence of SP on the performance of the single trial “uphill avoidance task” was tested. The post-trial injection of 1 ng SP (in 0.5 μl volume) led to significantly longer latencies in the uphill response. This result can be interpreted in terms of a facilitating effect of SP on performance of an inhibitory avoidance response.read more
Citations
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Journal ArticleDOI
The role of interactions between the cholinergic system and other neuromodulatory systems in learning and memory.
TL;DR: It is important to consider not only the independent contributions of age‐related changes in neuromodulatory systems to cognitive decline, but also the contribution of interactions between these systems to the learning and memory deficits associated with again and AD.
Book ChapterDOI
Afferents to basal forebrain cholinergic projection neurons: an update.
TL;DR: It is evident that BFC neurons in the rat are dispersed across a number of classically defined territories of the basal forebrain, rather than being arranged as distinct nuclear groups.
Journal ArticleDOI
The role of neuropeptides in learning: focus on the neurokinin substance P.
Joseph P. Huston,R. U. Hasenöhrl +1 more
TL;DR: The outcome of a series of experiments suggests that SP may not only be considered to have memory-promoting effects in normal animals, but can also improve functional recovery after unilateral 6-OHDA lesion of the substantia nigra and after lesions of the hippocampus, and can counteract age-related performance deficits.
Journal ArticleDOI
Modulation of memory processing by neuropeptide Y varies with brain injection site
TL;DR: NPY antibody had the opposite effect to that of NPY on memory retention suggesting that NPY has a physiological role as a modulator of memory processing within specific anatomical areas of the central nervous system.
Journal ArticleDOI
Intraseptal administration of muscimol produces dose-dependent memory impairments in the rat.
TL;DR: Data indicated that pharmacological manipulation of GABA-A receptors within the medial septum modifies working memory processes, and therefore, drugs or artificial cerebrospinal fluid administered immediately following the predelay session produced a dose-dependent impairment in maze performance.
References
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Book
The Rat Brain in Stereotaxic Coordinates
George Paxinos,Charles Watson +1 more
TL;DR: This paper presents a meta-analyses of the determinants of earthquake-triggered landsliding in the Czech Republic over a period of 18 months in order to establish a probabilistic framework for estimating the intensity of the earthquake.
Journal ArticleDOI
The Cholinergic Hypothesis of Geriatric Memory Dysfunction
Raymond T. Bartus,Raymond T. Bartus,Reginald L. Dean,Bernard Beer,Bernard Beer,Arnold S. Lippa,Arnold S. Lippa +6 more
TL;DR: Biochemical, electrophysiological, and pharmacological evidence supporting a role for cholinergic dysfunction in age-related memory disturbances is critically reviewed and an attempt has been made to identify pseudoissues, resolve certain controversies, and clarify misconceptions that have occurred in the literature.
Journal ArticleDOI
Distribution of substance P-like immunoreactivity in the central nervous system of the rat—I. Cell bodies and nerve terminals
TL;DR: It was difficult to identify substance-P immunoreactive axons in the rats studied, and further experimental studies are necessary to elucidate the projections of the substance P-immunoreactive neurons in the rat central nervous system.
Journal ArticleDOI
Evidence for a projection from the lateral preoptic area and substantia innominata to the 'mesencephalic locomotor region' in the rat.
Larry W. Swanson,Larry W. Swanson,Gordon J. Mogenson,Gordon J. Mogenson,C.R. Gerfen,C.R. Gerfen,P. Robinson,P. Robinson +7 more
TL;DR: It is demonstrated that fibers from both regions descend through the medial forebrain bundle and give rise in the pedunculopontine nucleus to a terminal field that contains many structures with the appearance of terminal boutons.
Journal ArticleDOI
Ramifications of the globus pallidus in the rat as indicated by patterns of immunohistochemistry
TL;DR: It is suggested that woolly fibers extending outward beyond the conventionally recognized borders of the pallidum represent pallidal elements innervated by enkephalin or substance P-positive fibers arising from ventromedial striatal regions in turn innervate by limbic structures.