Journal ArticleDOI
Suppression of hyphal formation and virulence of Candida albicans by natural and synthetic compounds.
Fazlurrahman Khan,Nilushi Indika Bamunuarachchi,Nilushi Indika Bamunuarachchi,Nazia Tabassum,Du-Min Jo,Mohammad Mansoob Khan,Young-Mog Kim +6 more
TLDR
In this article, various strategies employed to suppress filamentation, prevent biofilm formation, and reduce virulence of C. albicans hyphal morphogenesis are discussed, including natural or synthetic compounds, and their combination with other agents or nano-formulations.Abstract:
Candida albicans undergoes a morphological yeast-to-hyphal transition during infection, which plays a significant role in its pathogenesis. The filamentous morphology of the hyphal form has been identified as a virulence factor as it facilitates surface adherence, intertwining with biofilm, invasion, and damage to host tissues and organs. Hence, inhibition of filamentation in addition to biofilm formation is considered a viable strategy against C. albicans infections. Furthermore, a good understanding of the signaling pathways involved in response to environmental cues driving hyphal growth is also critical to an understanding of C. albicans pathogenicity and to develop novel therapies. In this review, first the clinical significance and transcriptional control of C. albicans hyphal morphogenesis are addressed. Then, various strategies employed to suppress filamentation, prevent biofilm formation, and reduce virulence are discussed. These strategies include the inhibition of C. albicans filament formation using natural or synthetic compounds, and their combination with other agents or nanoformulations.read more
Citations
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Phloroglucinol and Its Derivatives: Antimicrobial Properties toward Microbial Pathogens.
TL;DR: This review focuses on the use of PG and its derivatives to control microbial infection and the underlying mechanism of action and some of the various alternative strategies, such as the use in conjugation, nanoformulation, antibiotic combination, and encapsulation are thoroughly discussed.
Journal ArticleDOI
Real-time monitoring of mono- and dual-species biofilm formation and eradication using microfluidic platform
V. N. Tran,Fazlurrahman Khan,Won Han,Maknuna Luluil,Van Gia Truong,Hyo Geun Yun,Sungyoung Choi,Young-Mog Kim,Joong Ho Shin,Hyun Wook Kang +9 more
TL;DR: In this article , the authors employed a microfluidic technique to analyze the real-time formation of mono and dual-species (S. aureus and C. albicans) biofilms and noninvasive optical treatment of the established mature biofilm using 405-nm laser light.
Posted ContentDOI
Antifungal Activity of Linear and Disulfide-Cyclized Ultrashort Cationic Lipopeptides Alone and in Combination with Fluconazole against Vulvovaginal Candida spp.
TL;DR: Results indicate that combination therapy of VVC with USCLs and fluconazole at low non-toxic concentrations can be beneficial owing to the synergistic effect, however, further in vivo studies are needed to confirm this hypothesis.
Journal ArticleDOI
Biocontrol of Candida albicans by Antagonistic Microorganisms and Bioactive Compounds
TL;DR: The application of biological control strategies and the discovery of new compounds with antifungal activity will reduce the resistance of C. albicans, thereby promoting the development of novel diverse antif fungus drugs.
Journal ArticleDOI
Effects of nano-sized sodium hexametaphosphate on the viability, metabolism, matrix composition, and structure of dual-species biofilms of Streptococcus mutans and Candida albicans
Caio Sampaio,Alberto Carlos Botazzo Delbem,TY Hosida,Leonardo Antônio de Morais,Ana Vitória Pereira Fernandes,Francisco Nunes de Souza Neto,E. R. de Camargo,Douglas Roberto Monteiro,Juliano Pelim Pessan +8 more
TL;DR: HMPnano and F promoted higher antibiofilm effects compared with its micrometric counterpart for most of the parameters assessed, besides substantially affecting biofilms’ structure.
References
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