Synthesis and anti-inflammatory activities of mono-carbonyl analogues of curcumin
Guang Liang,Xiaokun Li,Xiaokun Li,Xiaokun Li,Li Chen,Shulin Yang,Xudong Wu,Elaine Studer,Emily C. Gurley,Phillip B. Hylemon,Faqing Ye,Yue-Ru Li,Huiping Zhou,Huiping Zhou +13 more
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TLDR
A series of curcumin analogues with more stable chemical structures were synthesized and several compounds showed an enhanced ability to inhibit lipopolysaccharide (LPS)-induced TNF-alpha and IL-6 synthesis in macrophages.About:
This article is published in Bioorganic & Medicinal Chemistry Letters.The article was published on 2008-02-15 and is currently open access. It has received 119 citations till now. The article focuses on the topics: Curcumin.read more
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Biological activities of curcumin and its analogues (Congeners) made by man and Mother Nature.
Preetha Anand,Sherin G. Thomas,Ajaikumar B. Kunnumakkara,Chitra Sundaram,Kuzhuvelil B. Harikumar,Bokyung Sung,Sheeja T. Tharakan,Krishna Misra,Indira K. Priyadarsini,Kallikat N. Rajasekharan,Bharat B. Aggarwal +10 more
TL;DR: This review focuses on the status of all these approaches in generating a "super curcumin," a homodimer of feruloylmethane containing a methoxy group and a hydroxyl group, a heptadiene with two Michael acceptors, and an alpha,beta-diketone.
Journal ArticleDOI
Recent developments in anti-inflammatory natural products.
Raju Gautam,Sanjay M. Jachak +1 more
TL;DR: The present review article describes anti‐inflammatory natural products derived from plants and marine sources reported during last decade, which belong to different chemical classes such as alkaloids, steroids, terpenoids, polyphenolics, phenylpropanoids, fatty acids and lipids, and various miscellaneous compounds.
Journal ArticleDOI
Curcumin‐loaded poly(ε‐caprolactone) nanofibres: Diabetic wound dressing with anti‐oxidant and anti‐inflammatory properties
Jonathan G. Merrell,Shaun W McLaughlin,Lu Tie,Cato T. Laurencin,Cato T. Laurencin,Alex F. Chen,Lakshmi S. Nair,Lakshmi S. Nair +7 more
TL;DR: Results demonstrate that the curcumin‐loaded PCL nanofibre matrix is bioactive and has potential as a wound dressing with anti‐oxidant and anti‐inflammatory properties.
Journal ArticleDOI
Exploration and synthesis of curcumin analogues with improved structural stability both in vitro and in vivo as cytotoxic agents.
Guang Liang,Lili Shao,Yi Wang,Chengguang Zhao,Yanhui Chu,Jian Xiao,Yu Zhao,Xiaokun Li,Xiaokun Li,Shulin Yang +9 more
TL;DR: The results suggest that the five-carbon linker-containing analogues of curcumin may be favorable for theCurcumin-based drug development both pharmacokinetically and pharmacologically.
Journal ArticleDOI
Curcumin: an orally bioavailable blocker of TNF and other pro-inflammatory biomarkers
TL;DR: An alternative, curcumin (diferuloylmethane), a component of turmeric (Curcuma longa) that is very inexpensive, orally bioavailable and highly safe in humans, yet can block TNF‐α action and production in in vitro models, in animal models and in humans is described.
References
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Obesity, inflammation, and insulin resistance.
TL;DR: The rapidly expanding body of animal and clinical data that support potential roles for inflammation in the pathogenesis of insulin resistance and type 2 diabetes mellitus are reviewed.
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Multiple biological activities of curcumin: a short review.
TL;DR: This review summarizes the most interesting in vitro and in vivo studies on the biological effects of curcumin, the constituent of turmeric, which has been widely studied for its anti-inflammatory, anti-angiogenic,Anti-oxidant, wound healing and anti-cancer effects.
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Curcumin: The Indian solid gold
TL;DR: Curcumin has been shown to exhibit antioxidant, anti-inflammatory, antiviral, antibacterial, antifungal, and anticancer activities and thus has a potential against various malignant diseases, diabetes, allergies, arthritis, Alzheimer's disease, and other chronic illnesses.
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Antioxidant and anti-inflammatory properties of curcumin.
TL;DR: Both antioxidant and anti-inflammatory properties of curcumin are described, the mode of action ofCurcumin, and its therapeutic usage against different pathological conditions are described.
Journal ArticleDOI
The role of TNF-α in chronic inflammatory conditions, intermediary metabolism, and cardiovascular risk
Calin D. Popa,Mihai G. Netea,Piet L. C. M. van Riel,Jos W. M. van der Meer,Anton F. H. Stalenhoef +4 more
TL;DR: Investigations assessing the impact of anti-TNF agents on intermediary metabolism suggest that TNF-alpha blockade may improve insulin resistance and lipid profiles in patients with chronic inflammatory diseases.