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Comprehensive Review in Current Developments of Imidazole‐Based Medicinal Chemistry
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TLDR
This work systematically gives a comprehensive review in current developments of imidazole‐based compounds in the whole range of medicinal chemistry as anticancer, antifungal, antibacterial, antitubercular, anti‐inflammatory, antineuropathic, antihypertensive, antihistaminic, antiparasitic, antiobesity, antiviral, and other medicinal agents, together with their potential applications in diagnostics and pathology.Abstract:
Imidazole ring is an important five-membered aromatic heterocycle widely present in natural products and synthetic molecules. The unique structural feature of imidazole ring with desirable electron-rich characteristic is beneficial for imidazole derivatives to readily bind with a variety of enzymes and receptors in biological systems through diverse weak interactions, thereby exhibiting broad bioactivities. The related research and developments of imidazole-based medicinal chemistry have become a rapidly developing and increasingly active topic. Particularly, numerous imidazole-based compounds as clinical drugs have been extensively used in the clinic to treat various types of diseases with high therapeutic potency, which have shown the enormous development value. This work systematically gives a comprehensive review in current developments of imidazole-based compounds in the whole range of medicinal chemistry as anticancer, antifungal, antibacterial, antitubercular, anti-inflammatory, antineuropathic, antihypertensive, antihistaminic, antiparasitic, antiobesity, antiviral, and other medicinal agents, together with their potential applications in diagnostics and pathology. It is hoped that this review will be helpful for new thoughts in the quest for rational designs of more active and less toxic imidazole-based medicinal drugs, as well as more effective diagnostic agents and pathologic probes.read more
Citations
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Analysis of the Structural Diversity, Substitution Patterns, and Frequency of Nitrogen Heterocycles among U.S. FDA Approved Pharmaceuticals
TL;DR: This review reports on the top 25 most commonly utilized nitrogen heterocycles found in pharmaceuticals, and reports detailed substitution patterns, highlight common architectural cores, and discuss unusual or rare structures.
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A Review on Recent Advances in Nitrogen-Containing Molecules and Their Biological Applications.
Nagaraju Kerru,Lalitha Gummidi,Suresh Maddila,Kranthi Kumar Gangu,Sreekantha B. Jonnalagadda +4 more
TL;DR: This review highlights the trends in the use of nitrogen-based moieties in drug design and the development of different potent and competent candidates against various diseases.
Journal ArticleDOI
Recent advance in oxazole-based medicinal chemistry.
TL;DR: This work systematically reviewed the recent researches and developments of the whole range of oxazole compounds as medicinal drugs, including antibacterial, antifungal, antiviral, antitubercular, anticancer, anti-inflammatory and analgesic, antidiabetic, antiparasitic, anti -obesitic,Anti-neuropathic, antioxidative as well as other biological activities.
Journal ArticleDOI
Antimicrobial cationic polymers: from structural design to functional control
TL;DR: This review summarizes the structural designs from primary to secondary structures, from covalent to noncovalent syntheses and from bulk to surface and will provide some guidelines for developing molecular engineering of antimicrobial cationic polymers with tailor-made structures and functions.
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Direct C-N coupling of imidazoles with aromatic and benzylic compounds via Electrooxidative C-H functionalization
TL;DR: A method for the C-N coupling of imidazoles based on electrooxidative C-H functionalization of aromatic and benzylic compounds has been developed, avoiding overoxidation and demonstrating the power of a P450 17 inhibiter and an antifungal agent having N-substitutedImidazole structures.
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Journal ArticleDOI
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SB-431542 is a potent and specific inhibitor of transforming growth factor-beta superfamily type I activin receptor-like kinase (ALK) receptors ALK4, ALK5, and ALK7.
Gareth J. Inman,Francisco J. Nicolás,James F. Callahan,John D. Harling,Laramie Mary Gaster,Alastair D. Reith,Nicholas J. Laping,Caroline S. Hill +7 more
TL;DR: It is demonstrated that SB-431542 is a selective inhibitor of endogenous activin and TGF-beta signaling but has no effect on BMP signaling.
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Rethinking amide bond synthesis
TL;DR: A new generation of amide-forming reactions are reviewed and summarize their potential application to current synthetic challenges, including the development of catalytic amide formation, the synthesis of therapeutic peptides and the preparation of modified peptide and proteins.
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Fluoro- and Chromogenic Chemodosimeters for Heavy Metal Ion Detection in Solution and Biospecimens
Duong Tuan Quang,Jong Seung Kim +1 more
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