Journal ArticleDOI
Synthesis of Anthranilic Diamide Derivatives Containing Moieties of Trifluoromethylpyridine and Hydrazone as Potential Anti-Viral Agents for Plants.
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TLDR
It is revealed that anthranilic diamide derivatives containing moieties of trifluoromethyl pyridine and hydrazone could be used as novel anti-viral agents for controlling the plant viruses.Abstract:
A series of novel anthranilic diamide derivatives (5a–5ab) containing moieties of trifluoromethylpyridine and hydrazone was designed and synthesized. The synthesized compounds were evaluated in viv...read more
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Expedient Discovery for Novel Antifungal Leads Targeting Succinate Dehydrogenase: Pyrazole-4-formylhydrazide Derivatives Bearing a Diphenyl Ether Fragment.
Xiaobin Wang,Xiaobin Wang,An Wang,Ling-Ling Qiu,Min Chen,Aimin Lu,Guo-Hua Li,Chunlong Yang,Wei Xue +8 more
TL;DR: The present work provided a non-negligible complement for the structural optimization of antifungal leads targeting SDH and indicated that the skeleton structure of title compounds should be optimized as an N'-(4-phenoxyphenyl)-1H-pyrazole-4-carbohydrazide scaffold.
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Novel Pyrazole-4-acetohydrazide Derivatives Potentially Targeting Fungal Succinate Dehydrogenase: Design, Synthesis, Three-Dimensional Quantitative Structure-Activity Relationship, and Molecular Docking.
Xiaobin Wang,Xiaobin Wang,Mengqi Wang,Ling Han,Fei Jin,Jian Jiao,Min Chen,Chunlong Yang,Wei Xue +8 more
TL;DR: A series of pyrazole-4-acetohydrazide derivatives potentially targeting fungal SDH were constructed and evaluated for their antifungal effects against Rhizoctonia solani, Fusarium graminearum, and Botrytis cinerea as mentioned in this paper.
Journal ArticleDOI
Purine Nucleoside Derivatives Containing a Sulfa Ethylamine Moiety: Design, Synthesis, Antiviral Activity, and Mechanism.
TL;DR: Compound 3 may further destroy the structure of the virus by binding to the coat protein of the TMV virus, thereby weakening the infectivity of theirus.
Journal ArticleDOI
Design, Synthesis, and Bioactivity of α-Ketoamide Derivatives Bearing a Vanillin Skeleton for Crop Diseases
TL;DR: The findings of transmission electron microscopic (TEM) and molecular docking indicated that the synthesized compounds exhibited strong and significant binding affinity to TMV coat protein (CP) and could obstruct the self-assembly and increment of TMV particles
Journal ArticleDOI
Design, synthesis and anti-TMV activity of novel α-aminophosphonate derivatives containing a chalcone moiety that induce resistance against plant disease and target the TMV coat protein.
TL;DR: The TEM morphological study ofTMV treated with B3 and B17 indicated that this series of target compounds may trigger the disassembly of TMV by interacting directly with TMV CP, which provides new insight for the discovery of antiviral compounds with two different mechanisms of action.
References
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Erin R. Johnson,Shahar Keinan,Paula Mori-Sánchez,Julia Contreras-García,Aron J. Cohen,Weitao Yang +5 more
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The Unique Role of Fluorine in the Design of Active Ingredients for Modern Crop Protection
TL;DR: The complex structure–activity relationships associated with biologically active molecules mean that the introduction of fluorine can lead to either an increase or a decrease in the efficacy of a compound depending on its changed mode of action, physicochemical properties, target interaction, or metabolic susceptibility and transformation.
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Protein-binding assays in biological liquids using microscale thermophoresis.
TL;DR: The affinity of the small-molecule inhibitor quercetin to its kinase PKA was determined in buffer and human serum, revealing a 400-fold reduced affinity in serum, which may allow to make more reliable conclusions on protein functionality, and may facilitate more efficient drug development.
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Cooperativity in Noncovalent Interactions.
Journal ArticleDOI
The tobacco mosaic virus particle: structure and assembly
TL;DR: A short account is given of the physical and chemical studies that have led to an understanding of the structure of the tobacco mosaic virus particle and how it is assembled from its constituent coat protein and RNA.