Journal ArticleDOI
Tailoring the porosity and pore size of electrospun synthetic human elastin scaffolds for dermal tissue engineering.
Jelena Rnjak-Kovacina,Steven G. Wise,Zhe Li,Peter K.M. Maitz,Cara J. Young,Yiwei Wang,Anthony S. Weiss +6 more
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TLDR
Low and high porosity synthetic human elastin scaffolds obtained by adapting low and high flow rates respectively during electrospinning presented increased fiber diameter and greater average pore size and over doubling of overall scaffold porosity.About:
This article is published in Biomaterials.The article was published on 2011-10-01. It has received 256 citations till now. The article focuses on the topics: Scaffold.read more
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Biomaterials for Skin Substitutes.
Mohammadali Sheikholeslam,Mohammadali Sheikholeslam,Meghan E. E. Wright,Marc G. Jeschke,Marc G. Jeschke,Saeid Amini-Nik,Saeid Amini-Nik +6 more
TL;DR: A composite scaffold fabricated from both natural and synthetic biomaterials may allow for the generation of skin substitutes that meet all clinical requirements including a tailored wound size and type, the degree of burn, the patient age, and the available preparation technique.
Journal ArticleDOI
Effect of orientation and density of nanotopography in dermal wound healing
TL;DR: Based on the experimental results, the nanopattern of 1:2 spacing ratio yielded the best wound healing performance in terms of migration speed, which seems similar to the natural organization of collagen fibers.
Journal ArticleDOI
Fabrication Aspects of Porous Biomaterials in Orthopedic Applications: A Review
Elham Babaie,Sarit B. Bhaduri +1 more
TL;DR: Various processing techniques such as partial sintering, sacrificial fugitives, foaming, freeze casting, metal injection molding, rapid prototyping, etc., and their associated parameters in designing of porous biomaterials are reviewed, with specific examples of their applications.
Journal ArticleDOI
Tropoelastin: a versatile, bioactive assembly module
Steven G. Wise,Giselle C. Yeo,Matti A. Hiob,Jelena Rnjak-Kovacina,David L. Kaplan,Martin K.C. Ng,Anthony S. Weiss +6 more
TL;DR: Tropoelastin is compatible with synthetic and natural co-polymers, expanding the applications of its potential use beyond traditional elastin-rich tissues and facilitating finer control of biomaterial properties and the design of next-generation tailored bioactive materials.
Journal ArticleDOI
Collagen and Elastin Biomaterials for the Fabrication of Engineered Living Tissues
David Miranda-Nieves,David Miranda-Nieves,Elliot L. Chaikof,Elliot L. Chaikof,Elliot L. Chaikof +4 more
TL;DR: The notion that many tissues in the human body represent a reinforced composite of collagen and elastin is proposed and, based on biochemical and biomechanical considerations, it is suggested that future tissue-engineering efforts consider direct incorporation of collagen
References
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Production of a tissue-like structure by contraction of collagen lattices by human fibroblasts of different proliferative potential in vitro.
TL;DR: Fibroblasts of high population doubling level propagated in vitro, which have left the cell cycle, can carry out the contraction at least as efficiently as cycling cells.
Production of a tissue-like structure by contraction of collagen lattices by human fibroblasts of different proliferative
TL;DR: Fibroblasts of high population doubling level propagated in vitro, which have left the cell cycle, can carry out the contraction at least as efficiently as cycling cells as discussed by the authors, and the potential uses of the system as an immu- nologically tolerated "tissue" for wound hea ing and as a model for studying fibroblast function are discussed.
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ImageJ for microscopy
TL;DR: The near-comprehensive range of import filters that allow easy access to image and meta-data, a broad suite processing and analysis routine, and enthusiastic support from a friendly mailing list are invaluable for all microscopy labs and facilities-not just those on a budget.
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Electrospun Poly(ε-caprolactone) Microfiber and Multilayer Nanofiber/Microfiber Scaffolds: Characterization of Scaffolds and Measurement of Cellular Infiltration
TL;DR: The scaffold design presented in this study allows for cellular infiltration into the scaffolds while at the same time providing nanofibers as a physical mimicry of extracellular matrix.
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Formation of fibers by electrospinning.
TL;DR: Electrostatic fiber formation, also known as "electrospinning", has emerged in recent years as the popular choice for producing continuous threads, fiber arrays and nonwoven fabrics with fiber diameters below 1 microm for a wide range of materials.