Journal ArticleDOI
Targeted lymphatic transport and modified systemic distribution of CI-976, a lipophilic lipid-regulator drug, via a formulation approach
Reads0
Chats0
TLDR
CI-976 is a poorly water soluble lipid regulator with good solubility in triglycerides and a high octanol:water partition coefficient which suggest significant lymphatic transport following gastroin-testinal absorption, which may not be representative of total systemic bioavailability of drug.About:
This article is published in International Journal of Pharmaceutics.The article was published on 1994-08-01. It has received 64 citations till now. The article focuses on the topics: Bioavailability & Drug carrier.read more
Citations
More filters
Journal ArticleDOI
Lipids and lipid-based formulations: optimizing the oral delivery of lipophilic drugs
TL;DR: The mechanisms by which lipids and lipidic excipients affect the oral absorption of lipophilic drugs are detailed and a perspective on the possible future applications of lipid-based delivery systems is provided.
Journal ArticleDOI
Self-emulsifying drug delivery systems (SEDDS) for improved oral delivery of lipophilic drugs.
R. Neslihan Gürsoy,Simon Benita +1 more
TL;DR: Self-emulsifying drug delivery systems (SEDDS), which are isotropic mixtures of oils, surfactants, solvents and co-solvents/surfactants, can be used for the design of formulations in order to improve the oral absorption of highly lipophilic drug compounds as discussed by the authors.
Journal ArticleDOI
Oral lipid-based formulations
TL;DR: This commentary provides a comprehensive summary of the development, characterization, and utilization of oral lipid-based formulations, from both physicochemical and biopharmaceutical perspectives.
Journal ArticleDOI
Self-dispersing lipid formulations for improving oral absorption of lipophilic drugs.
Tatyana Gershanik,Simon Benita +1 more
TL;DR: This review outlines SDLFs as one of the most promising approaches to overcome the formulation difficulties of these hydrophobic/lipophilic drugs.
Journal ArticleDOI
Lipids, lipophilic drugs, and oral drug delivery-some emerging concepts.
TL;DR: This mini-review describes some emerging formulation and biopharmaceutic strategies that hold promise for better understanding how to design and evaluate lipid-based dose forms.
References
More filters
Book
Textbook of Medical Physiology
Arthur C. Guyton,John E. Hall +1 more
TL;DR: Textbook of medical physiology , Textbook ofmedical physiology , کتابخانه دیجیتال جندی شاپور اهواز
Journal ArticleDOI
Textbook of Medical Physiology
TL;DR: Textbook of medical physiology, Textbook of Medical Physiology, this paper, textbook of medicine, textbooks of medical science, text book of medical literature, textbook medical physiology.
Journal ArticleDOI
Absorption, Transport and Metabolism of Vitamin E
TL;DR: Clinical evidence from heavy drinkers and from experimental work in rats suggests that alcohol may increase oxidation of alpha-tocopherol, causing reduced tissue concentrations ofAlpha-Tocopherol.
Journal ArticleDOI
Comparison of CI-976, an ACAT inhibitor, and selected lipid-lowering agents for antiatherosclerotic activity in iliac-femoral and thoracic aortic lesions. A biochemical, morphological, and morphometric evaluation.
TL;DR: Inhibition of ACAT within the arterial wall by the potent and specific ACAT inhibitor CI-976, even in the absence of plasma cholesterol lowering, can result in the inhibition of atherosclerotic lesion progression and can enhance regression.
Journal ArticleDOI
Transport of lipophilic molecules by the intestinal lymphatic system
TL;DR: The factors involved in the transport of highly lipophilic drugs by the intestinal lymphatics are described and potential means for the promotion of intestinal lymphatic transport of Lipophilic molecules are discussed.