Journal ArticleDOI
Temporal summation of pain from mechanical stimulation of muscle tissue in normal controls and subjects with fibromyalgia syndrome.
Roland Staud,Richard C Cannon,Andre P. Mauderli,Michael E. Robinson,Donald D. Price,Charles J. Vierck +5 more
TLDR
Temporal summation of pain and after‐sensations elicited by thermal stimulation of the skin are moderately enhanced for FMS subjects, and normal input from muscle nociceptors appears to underlie production of central sensitization in FMS that generalizes to input from cutaneous nocICEptors.Abstract:
Individuals diagnosed with fibromyalgia syndrome (FMS) report chronic pain that is frequently worsened by physical activity and improved by rest. Palpation of muscle and tendinous structures suggests that nociceptors in deep tissues are abnormally sensitive in FMS, but methods of controlled mechanical stimulation of muscles are needed to better characterize the sensitivity of deep tissues. Accordingly, force-controlled mechanical stimulation was applied to the flexor digitorum muscle of the forearm in a series of brief contacts (15 stimuli, each of 1s duration, at 3 or 5s interstimulus intervals). Repetitive stimulation was utilized to determine whether temporal summation of deep muscular pain would occur for normal subjects and would be enhanced for FMS subjects. Moderate temporal summation of deep pain was observed for normal controls (NC), and temporal summation was greatly exaggerated for FMS subjects. Temporal summation for FMS subjects occurred at substantially lower forces and at a lower frequency of stimulation. Furthermore, painful after-sensations were greater in amplitude and more prolonged for FMS subjects. These observations complement a previous demonstration that temporal summation of pain and after-sensations elicited by thermal stimulation of the skin are moderately enhanced for FMS subjects. Abnormal input from muscle nociceptors appears to underlie production of central sensitization in FMS that generalizes to input from cutaneous nociceptors.read more
Citations
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Journal ArticleDOI
Central sensitization: implications for the diagnosis and treatment of pain.
TL;DR: Diagnostic criteria to establish the presence of central sensitization in patients will greatly assist the phenotyping of patients for choosing treatments that produce analgesia by normalizing hyperexcitable central neural activity.
Journal ArticleDOI
Central sensitization and LTP: do pain and memory share similar mechanisms?
TL;DR: Analysis of the molecular mechanisms underlying the generation and maintenance of central sensitization and LTP indicates that, although there are differences between the synaptic plasticity contributing to memory and pain, there are also striking similarities.
Journal ArticleDOI
Studying sex and gender differences in pain and analgesia: a consensus report
Joel D. Greenspan,Rebecca M. Craft,Linda LeResche,Lars Arendt-Nielsen,Karen J. Berkley,Roger B. Fillingim,Michael S. Gold,Anita Holdcroft,Stefan Lautenbacher,Emeran A. Mayer,Jeffrey S. Mogil,Anne Z. Murphy,Richard J. Traub +12 more
TL;DR: In this article, members of the Sex, Gender and Pain Special Interest Group of the International Association for the Study of Pain met to discuss the following: (1) what is known about sex and gender differences in pain and analgesia; (2) what are the "best practice" guidelines for pain research with respect to sex this article.
Journal ArticleDOI
Sensitization in patients with painful knee osteoarthritis.
Lars Arendt-Nielsen,HongLing Nie,Mogens Berg Laursen,Birgitte Schantz Laursen,Pascal Madeleine,Ole Simonsen,Thomas Graven-Nielsen +6 more
TL;DR: OA patients showed a significant facilitation of temporal summation from both the knee and TA and had significantly less DNIC as compared with controls, and the importance of central sensitization as an important manifestation in knee OA is highlighted.
Consensus report Studying sex and gender differences in pain and analgesia: A consensus report
Joel D. Greenspan,Rebecca M. Craft,Linda LeResche,Lars Arendt-Nielsen,Karen J. Berkley,Roger B. Fillingim,Michael S. Gold,Anita Holdcroft,Stefan Lautenbacher,Emeran A. Mayer,Jeffrey S. Mogil,Anne Z. Murphy,Richard J. Traub +12 more
TL;DR: This document is intended to serve as a utilitarian and thought-provoking guide for future research on sex and gender differences in pain and analgesia, both for those currently working in this field as well as those still wondering, "Do I really need to study females?"
References
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Journal ArticleDOI
The American College of Rheumatology 1990 Criteria for the Classification of Fibromyalgia. Report of the Multicenter Criteria Committee.
Frederick Wolfe,Hugh A. Smythe,Muhammad B. Yunus,Robert M. Bennett,Claire Bombardier,Don L. Goldenberg,Peter Tugwell,Stephen M. Campbell,Micha Abeles,Patricia Clark,Adel G. Fam,Stephen J. Farber,Justus J. Fiechtner,C. Michael Franklin,Robert A. Gatter,Daniel Hamaty,James A. Lessard,Alan S. Lichtbroun,Alfonse T. Masi,Glenn A. McCain,W. John Reynolds,Thomas J. Romano,I. Jon Russell,Robert P. Sheon +23 more
TL;DR: Criteria for the classification of fibromyalgia are widespread pain in combination with 2) tenderness at 11 or more of the 18 specific tender point sites, and no exclusions are made for the presence of concomitant radiographic or laboratory abnormalities.
Journal ArticleDOI
Evidence for a role of the NMDA receptor in the frequency dependent potentiation of deep rat dorsal horn nociceptive neurones following c fibre stimulation.
TL;DR: The results suggest an involvement of the NMDA receptor in this potentiation of dorsal horn nociceptive neurones in the intact halothane anaesthetized rat.
Journal ArticleDOI
Nociception from skeletal muscle in relation to clinical muscle pain.
Journal ArticleDOI
Abnormal sensitization and temporal summation of second pain (wind-up) in patients with fibromyalgia syndrome
TL;DR: Psychophysical evidence is obtained for the possibility that input to central nociceptive pathways is abnormally processed in individuals with long standing fibromyalgia syndrome and for an understanding of the underlying pathophysiological basis.
Journal ArticleDOI
Evidence for involvement of N-methylaspartate receptors in 'wind-up' of class 2 neurones in the dorsal horn of the rat
Stephen N. Davies,David Lodge +1 more
TL;DR: N-Methylaspartate receptors appear to contribute to the wind-up, but not the initial response, of class 2 neurones in the rat, while Iontophoretic or intravenous ketamine had no consistent effect on theInitial response but consistently reduced wind- up.
Related Papers (5)
The American College of Rheumatology 1990 Criteria for the Classification of Fibromyalgia. Report of the Multicenter Criteria Committee.
Frederick Wolfe,Hugh A. Smythe,Muhammad B. Yunus,Robert M. Bennett,Claire Bombardier,Don L. Goldenberg,Peter Tugwell,Stephen M. Campbell,Micha Abeles,Patricia Clark,Adel G. Fam,Stephen J. Farber,Justus J. Fiechtner,C. Michael Franklin,Robert A. Gatter,Daniel Hamaty,James A. Lessard,Alan S. Lichtbroun,Alfonse T. Masi,Glenn A. McCain,W. John Reynolds,Thomas J. Romano,I. Jon Russell,Robert P. Sheon +23 more