Journal ArticleDOI
The absolute configurations of the animal metabolite, equol, three naturally occurring isoflavans, and one natural isoflavanquinone
Kazu Kurosawa,W. D. Ollis,Brian T. Redman,I. O. Sutherland,Otto R. Gottlieb,H. Magalhães Alves +5 more
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This article is published in Chemical Communications (london).The article was published on 1968-01-01. It has received 17 citations till now. The article focuses on the topics: Equol & Metabolite.read more
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Journal ArticleDOI
Circular dichroism, a powerful tool for the assessment of absolute configuration of flavonoids.
TL;DR: Results relevant to the correlation of circular dichroic data and the absolute configuration of the diastereoisomers of some of the above classes of compounds will be discussed.
Journal ArticleDOI
S-Equol, a potent ligand for estrogen receptor β, is the exclusive enantiomeric form of the soy isoflavone metabolite produced by human intestinal bacterial flora
Kenneth D.R. Setchell,Carlo Alfredo Clerici,Edwin D. Lephart,Sidney J Cole,Claire Heenan,Danilo Castellani,Brian Wolfe,Linda Nechemias-Zimmer,Nadine M Brown,Trent D. Lund,Robert J. Handa,James E. Heubi,James E. Heubi +12 more
TL;DR: Humans have acquired an ability to exclusively synthesize S-equol from the precursor soy isoflavone daidzein, and it is significant that this enantiomer has a relatively high affinity for estrogen receptor beta.
Journal ArticleDOI
Equol, a natural estrogenic metabolite from soy isoflavones: convenient preparation and resolution of R- and S-equols and their differing binding and biological activity through estrogen receptors alpha and beta.
Rajeev S. Muthyala,Young H. Ju,Shubin Sheng,Lee D. Williams,Daniel R. Doerge,Benita S. Katzenellenbogen,William G. Helferich,John A. Katzenellenbogen +7 more
TL;DR: An efficient and convenient method to prepare (+/-)-equol from available isoflavanoid precursors is developed and the activities of the enantiomers on the two estrogen receptors, ERalpha and ERbeta are studied for the first time.
Patent
Compositions and products containing s-equol, and methods for their making
TL;DR: In this article, the S-equol enantiomer can be produced in a biological synthesis from the metabolism of an isoflavone by an organism, which can be used to make articles of commerce such as food supplements, pharmaceuticals, and medicaments.
Journal ArticleDOI
Prenylated Phenolic Compounds from the Aerial Parts of Glycyrrhiza uralensis as PTP1B and α-Glucosidase Inhibitors.
TL;DR: An ethanol extract of the aerial parts of G. uralensis showed antidiabetic effects on db/db mice, and the structures were identified by NMR and HRESIMS data analyses and the absolute configurations were established by comparing the calculated and experimental ECD spectroscopic data.