Journal ArticleDOI
The Acid Strength of the -SH Group in Cysteine and Related Compounds
Ruth E. Benesch,Reinhold Benesch +1 more
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Thermochemistry of Proton-Coupled Electron Transfer Reagents and its Implications
TL;DR: This issue discusses proton-coupled electron transfer or PCET processes, which are central to a great many chemical and biochemical processes, from biological catalysis and energy transduction, to bulk industrial chemical processes, to new approaches to solar energy conversion.
Book ChapterDOI
Ultraviolet spectra Of Proteins and Amino Acids
TL;DR: This chapter reviews that the simplest way of accounting for the absorption spectrum of a protein is as the sum of the spectra of its components, and discusses that the failure of perfect additivity of the component absorptivities affords the possibility of obtaining structural information about proteins.
Book ChapterDOI
The Glutathione S‐Transferases: A Group of Multifunctional Detoxification Proteins
TL;DR: There appears to be sufficient enzyme for all three roles in detoxification of glutathione S-transferases; the binding of bilirubin is an example of a major function common to all higher species.
Journal ArticleDOI
Mitochondria-Targeted Chemotherapeutics: The Rational Design of Gold(I) N-Heterocyclic Carbene Complexes That Are Selectively Toxic to Cancer Cells and Target Protein Selenols in Preference to Thiols
James L. Hickey,Rasha A. Ruhayel,Peter J. Barnard,Murray V. Baker,Susan J. Berners-Price,Aleksandra Filipovska +5 more
TL;DR: A family of lipophilic, cationic Au(I) complexes of N-heterocyclic carbenes (NHCs) have been designed as new mitochondria-targeted antitumor agents that combine both selective mitochondrial accumulation and selective thioredoxin reductase inhibition properties within a single molecule.
Journal ArticleDOI
The Role of Glutathione in Detoxication
TL;DR: Whether the reaction be enzymic or nonenzymic, conjugation with GSH is a very important means of detoxication accounting in some cases for up to 60% of the biliary metabolites.