Open AccessJournal Article
The anti-virus and hepatoprotective effect of bicyclol and its mechanism of action
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TLDR
The results of mechanistic study on bicyclol indicated that bicyclol is not an inhibitor of transaminase, but a cell membrane protector through elinmination of free radicals.Abstract:
Bicyclol is a synthetic novel anti hepatitis drugIt has remarkable hepatoprotective and certain anti hepatitis virus actionsOral administration of 50,100,200 mg·kg -1 bicyclol protected livers of mice from damage induced by CCl 4,D galactosamine,acetoaminophen and BCGplus lipopolysacharides (LPS) expressed in decreases of ALT and AST as well as morphological damage of liver tissuesAddition of bicyclol to the cultivated 2215 cell line inhibited secretion of HBeAg and HBsAg as well as HBV DNA levelThe results of mechanistic study on bicyclol indicated that bicyclol is not an inhibitor of transaminase,but a cell membrane protector through elinmination of free radicalsMoreover,bicyclol can protect hepatocyte nuclear DNA from damage and reduce the apoptosis induced by immuno stimulating compound Con A [read more
Citations
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New Perspectives on How to Discover Drugs from Herbal Medicines: CAM's Outstanding Contribution to Modern Therapeutics.
Si Yuan Pan,Shu-Feng Zhou,Si Hua Gao,Zhi-Ling Yu,Shuo Feng Zhang,Min Ke Tang,Jian Ning Sun,Dik-Lung Ma,Yifan Han,Wang Fun Fong,Kam Ming Ko +10 more
TL;DR: The prospect of drug discovery from herbal medicines in the postgenomic era was made with the provision of future directions in this area of drug development.
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Biological screening of natural products and drug innovation in China.
TL;DR: The transition from traditional to empirical and to molecular screening will certainly increase the probability of discovering new leads and drug candidates from natural products.
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Bicyclol: a novel drug for treating chronic viral hepatitis B and C
TL;DR: In combination therapy of bicyclol with interferon alpha, lamivudine and adefovir dipivoxil in HBV or HCV, bicyclol may potentiate the anti-viral efficacy and reduce YMDD mutant and side effects.
Journal ArticleDOI
Protective effect of bicyclol on acute hepatic failure induced by lipopolysaccharide and D-galactosamine in mice.
Huiping Wang,Yan Li +1 more
TL;DR: The results suggest that bicyclol has remarkable hepatoprotective effects on LPS/D-galactosamine-induced liver injury and the possible mechanism is related to its anti-inflammatory action.
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Protective effect of bicyclol on acute alcohol-induced liver injury in mice.
Jing Zhao,Hui Chen,Yan Li +2 more
TL;DR: The protective effect of bicyclol on alcohol-induced hepatotoxicity was mainly due to its ability to attenuate oxidative stress, suppress the cytokine expression at both protein and gene level, and inhibit the activation of Kupffer cells by decreasing plasma endotoxin level and CD14 expression.
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