The application of halloysite tubule nanoclay in drug delivery
TLDR
Natural and biocompatible clay nanotubes are among the best inorganic materials for drug nanoformulations and are expected to be used primarily for non-injectable drug formulations, such as topical and oral dosage forms, cosmetics, as well as for composite materials with enhanced therapeutic effects.Abstract:
Introduction: Natural and biocompatible clay nanotubes are among the best inorganic materials for drug nanoformulations. These halloysite tubes with SiO2 on the outermost surface have diameter of ca. 50 nm, length around 1 micrometer and may be loaded with drugs at 10-30 wt. %. Narrow tube openings allow for controllable sustained drug release for hours, days or even weeks.Areas covered: Physical-chemical properties of these nanotubes are described followed by examples of drug-loading capabilities, release characteristics, and control of duration of release through the end tube capping with polymers. Development of halloysite–polymer composites such as tissue scaffolds and bone cement/dentist resin formulations with enhanced mechanical properties and extension of the drug release to 2-3 weeks are described. Examples of the compression properties of halloysite in tablets and capsules are also shown.Expert opinion: We expect that clay nanotubes will be used primarily for non-injectable drug formulat...read more
Citations
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An assembly of organic-inorganic composites using halloysite clay nanotubes
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Clay nanoparticles for regenerative medicine and biomaterial design: A review of clay bioactivity.
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References
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Halloysite Clay Nanotubes for Loading and Sustained Release of Functional Compounds.
TL;DR: Halloysite nanotubes are a promising mesoporous media for catalytic nanoparticles that may be seeded on the tube surface or synthesized exclusively in the lumens, providing enhanced catalytic properties, especially at high temperatures.
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Cytocompatibility and Uptake of Halloysite Clay Nanotubes
Viviana Vergaro,Elshad Abdullayev,Yuri Lvov,Andre Zeitoun,Roberto Cingolani,Ross Rinaldi,Stefano Leporatti +6 more
TL;DR: Quantitative Trypan blue and MTT measurements performed with two neoplastic cell lines model systems as a function of the nanotubes concentration and incubation time indicate that halloysite exhibits a high level of biocompatibility and very low cytotoxicity, rendering it a good candidate for household materials and medicine.
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Chitosan–halloysite nanotubes nanocomposite scaffolds for tissue engineering
TL;DR: The determination of mechanical and thermal properties demonstrated that the NC scaffolds exhibited significant enhancement in compressive strength, compressive modulus, and thermal stability compared with the pure chitosan scaffold.
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Drug loaded homogeneous electrospun PCL/gelatin hybrid nanofiber structures for anti-infective tissue regeneration membranes
Jiajia Xue,Min He,Hao Liu,Yuzhao Niu,Aileen Crawford,P. D. Coates,Dafu Chen,Rui Shi,Liqun Zhang +8 more
TL;DR: The potential for using MNA-loaded PCL/gelatin electrospun membranes as anti-infective GTR/GBR membranes to optimize clinical application of GTR-GBR strategies is indicated.
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In-vitro release characteristics of tetracycline HCl, khellin and nicotinamide adenine dineculeotide from halloysite; a cylindrical mineral
Ronald R. Price,B P Gaber,Y Lvov +2 more
TL;DR: A unique low cost alternative microcylindrical delivery system: the clay mineral halloysite, is investigated, which is capable of retaining and releasing a range of active ingredients.